Modulating neuroinflammation in COVID-19 patients with obsessive-compulsive disorder

Vera Nezgovorova, Casara Jean Ferretti, Stefano Pallanti, Eric Hollander

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Exacerbation of symptoms of obsessive-compulsive disorder (OCD) during COVID-19 or new onset of the OCD symptoms resulting from COVID-19 infection is an understudied area of research. It is possible that increased proinflammatory immune status is associated with the onset of obsessive-compulsive symptoms in patients with COVID-19 and that targeted anti-inflammatory treatments for COVID-19 infection can mitigate the new onset of Obsessive-Compulsive (OC) spectrum symptoms. In this review, we cover OCD pathogenesis as related to COVID-19, summarize the impact of cytokines on behavior, and suggest that anti-cytokine treatments can help mitigate post-COVID-19 and new onset of the OC symptoms.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalJournal of Psychiatric Research
StatePublished - May 2022


  • COVID-19
  • Neuroinflammation
  • OCD
  • Obsessive-compulsive disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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