Modifiable risk factors for migraine progression

Marcelo E. Bigal, Richard B. Lipton

Research output: Contribution to journalReview articlepeer-review

249 Scopus citations


Migraine is a chronic-recurrent disorder that progresses in some individuals. Transformed migraine is the result of this progression. Since migraine does not progress in most patients, identifying the risk factors for progression has emerged as a very important public health priority. If risk factors can be identified, that might provide a foundation for more aggressive preventive intervention. Risk factors for progression may be divided into non-remediable (gender, age, race) and remediable categories. In this paper, we focus on several already identified remediable risk factors, including frequency of migraine attacks, obesity, acute medication overuse, caffeine overuse, stressful life events, depression, and sleep disorders. We present the evidence for each risk factor and discuss possible interventions to address them.

Original languageEnglish (US)
Pages (from-to)1334-1343
Number of pages10
Issue number9
StatePublished - Oct 2006


  • Migraine progression
  • Modifiable risk factors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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