Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Chaithanya Ganji, Veda Muppala, Musaab Khan, Ganji Purnachandra Nagaraju, Batoul Farran

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Mitochondria are the powerhouses of cells and modulate the essential metabolic functions required for cellular survival. Various mitochondrial pathways, such as oxidative phosphorylation or production of reactive oxygen species (ROS) are dysregulated during cancer growth and development, rendering them attractive targets against cancer. Thus, the delivery of antitumor agents to mitochondria has emerged as a potential approach for treating cancer. Recent advances in nanotechnology have provided innovative solutions for overcoming the physical barriers posed by the structure of mitochondrial organelles, and have enabled the development of efficient mitochondrial nanoplatforms. In this review, we examine the importance of mitochondria during neoplastic development, explore the most recent smart designs of nano-based systems aimed at targeting mitochondria, and highlight key mitochondrial pathways in cancer cells.

Original languageEnglish (US)
Article number103469
JournalDrug Discovery Today
Issue number3
StatePublished - Mar 2023


  • cancer
  • drug
  • mitochondria
  • nanoparticles
  • therapy

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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