TY - JOUR
T1 - Mitigating age-related somatic mutation burden
AU - Vijg, Jan
AU - Schumacher, Björn
AU - Abakir, Abdulkadir
AU - Antonov, Michael
AU - Bradley, Chris
AU - Cagan, Alex
AU - Church, George
AU - Gladyshev, Vadim N.
AU - Gorbunova, Vera
AU - Maslov, Alexander Y.
AU - Reik, Wolf
AU - Sharifi, Samim
AU - Suh, Yousin
AU - Walsh, Kenneth
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/7
Y1 - 2023/7
N2 - Genomes are inherently unstable and require constant DNA repair to maintain their genetic information. However, selective pressure has optimized repair mechanisms in somatic cells only to allow transmitting genetic information to the next generation, not to maximize sequence integrity long beyond the reproductive age. Recent studies have confirmed that somatic mutations, due to errors during genome repair and replication, accumulate in tissues and organs of humans and model organisms. Here, we describe recent advances in the quantitative analysis of somatic mutations in vivo. We also review evidence for or against a possible causal role of somatic mutations in aging. Finally, we discuss options to prevent, delay or eliminate de novo, random somatic mutations as a cause of aging.
AB - Genomes are inherently unstable and require constant DNA repair to maintain their genetic information. However, selective pressure has optimized repair mechanisms in somatic cells only to allow transmitting genetic information to the next generation, not to maximize sequence integrity long beyond the reproductive age. Recent studies have confirmed that somatic mutations, due to errors during genome repair and replication, accumulate in tissues and organs of humans and model organisms. Here, we describe recent advances in the quantitative analysis of somatic mutations in vivo. We also review evidence for or against a possible causal role of somatic mutations in aging. Finally, we discuss options to prevent, delay or eliminate de novo, random somatic mutations as a cause of aging.
KW - aging
KW - cancer
KW - chromatin organization
KW - clonal hematopoiesis
KW - germline versus somatic genome
KW - somatic mutations
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U2 - 10.1016/j.molmed.2023.04.002
DO - 10.1016/j.molmed.2023.04.002
M3 - Review article
C2 - 37121869
AN - SCOPUS:85153871970
SN - 1471-4914
VL - 29
SP - 530
EP - 540
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 7
ER -