Mining the epigenetic landscape in ALL

Lindsay M. Lafave; Ross L. Levine

doi:10.1038/ng.2808

Mining the epigenetic landscape in ALL

Lindsay M. Lafave
, Ross L. Levine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.

Original language	English (US)
Pages (from-to)	1269-1270
Number of pages	2
Journal	Nature Genetics
Volume	45
Issue number	11
DOIs	https://doi.org/10.1038/ng.2808
State	Published - Nov 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Genetics

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10.1038/ng.2808

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title = "Mining the epigenetic landscape in ALL",

abstract = "The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.",

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AB - The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.

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UR - https://www.scopus.com/pages/publications/84891689468#tab=citedBy

U2 - 10.1038/ng.2808

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JO - Nature Genetics

JF - Nature Genetics

IS - 11

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Mining the epigenetic landscape in ALL

Abstract

UN SDGs

ASJC Scopus subject areas

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