Miller-Dieker syndrome: A disorder affecting specific pathways of neuronal migration

L. A. Alvarez; T. Yamamoto; B. Wong; T. J. Resnick; J. F. Llena; S. L. Moshé

doi:10.1212/WNL.36.4.489

Miller-Dieker syndrome: A disorder affecting specific pathways of neuronal migration

L. A. Alvarez, T. Yamamoto, B. Wong, T. J. Resnick, J. F. Llena, S. L. Moshé

Research output: Contribution to journal › Article › peer-review

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Abstract

A patient with the typical craniofacial features and clinical course of Miller-Dieker syndrome (MDS) was found on autopsy to have focal pachygyria rather than lissencephaly. The brainstem and cerebellum were hypoplastic, but thalami and basal ganglia were normal. We believe that MDS is a syndrome in which multiple specific pathways of neuronal migration are affected selectively, such as migration to the neocortex, migration via corpus pontobulbare, and cerebellar migration. However, another migration pathway (via corpus gangliothalamicum) is spared.

Original language	English (US)
Pages (from-to)	489-493
Number of pages	5
Journal	Neurology
Volume	36
Issue number	4
DOIs	https://doi.org/10.1212/WNL.36.4.489
State	Published - Jan 1 1986
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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AU - Llena, J. F.

AU - Moshé, S. L.

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AB - A patient with the typical craniofacial features and clinical course of Miller-Dieker syndrome (MDS) was found on autopsy to have focal pachygyria rather than lissencephaly. The brainstem and cerebellum were hypoplastic, but thalami and basal ganglia were normal. We believe that MDS is a syndrome in which multiple specific pathways of neuronal migration are affected selectively, such as migration to the neocortex, migration via corpus pontobulbare, and cerebellar migration. However, another migration pathway (via corpus gangliothalamicum) is spared.

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Miller-Dieker syndrome: A disorder affecting specific pathways of neuronal migration

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