Midbrain serotonergic neurons are central pH chemoreceptors

Christopher A. Severson; Wengang Wang; Vincent A. Pieribone; Carolin I. Dohle; George B. Richerson

doi:10.1038/nn1130

Midbrain serotonergic neurons are central pH chemoreceptors

Christopher A. Severson, Wengang Wang, Vincent A. Pieribone, Carolin I. Dohle, George B. Richerson

Research output: Contribution to journal › Article › peer-review

168 Scopus citations

Abstract

Serotonergic neurons in the medulla are central respiratory chemoreceptors. Here we show that serotonergic neurons in the midbrain of rats are also highly chemosensitive to small changes in CO₂/pH and are closely associated with large penetrating arteries. We propose that midbrain raphé neurons are sensors of blood CO₂ that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis.

Original language	English (US)
Pages (from-to)	1139-1140
Number of pages	2
Journal	Nature Neuroscience
Volume	6
Issue number	11
DOIs	https://doi.org/10.1038/nn1130
State	Published - Nov 2003
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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@article{31061071dd0b430683a7a406456bac70,

title = "Midbrain serotonergic neurons are central pH chemoreceptors",

abstract = "Serotonergic neurons in the medulla are central respiratory chemoreceptors. Here we show that serotonergic neurons in the midbrain of rats are also highly chemosensitive to small changes in CO2/pH and are closely associated with large penetrating arteries. We propose that midbrain raph{\'e} neurons are sensors of blood CO2 that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis.",

author = "Severson, {Christopher A.} and Wengang Wang and Pieribone, {Vincent A.} and Dohle, {Carolin I.} and Richerson, {George B.}",

note = "Funding Information: This work was supported by the US National Institutes of Health (C.A.S., W.W., V.A.P. & G.B.R.), the Department of Veterans Affairs (G.B.R.) and the German Merit Foundation (C.I.D.).",

year = "2003",

month = nov,

doi = "10.1038/nn1130",

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volume = "6",

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T1 - Midbrain serotonergic neurons are central pH chemoreceptors

AU - Severson, Christopher A.

AU - Wang, Wengang

AU - Pieribone, Vincent A.

AU - Dohle, Carolin I.

AU - Richerson, George B.

N1 - Funding Information: This work was supported by the US National Institutes of Health (C.A.S., W.W., V.A.P. & G.B.R.), the Department of Veterans Affairs (G.B.R.) and the German Merit Foundation (C.I.D.).

PY - 2003/11

Y1 - 2003/11

N2 - Serotonergic neurons in the medulla are central respiratory chemoreceptors. Here we show that serotonergic neurons in the midbrain of rats are also highly chemosensitive to small changes in CO2/pH and are closely associated with large penetrating arteries. We propose that midbrain raphé neurons are sensors of blood CO2 that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis.

AB - Serotonergic neurons in the medulla are central respiratory chemoreceptors. Here we show that serotonergic neurons in the midbrain of rats are also highly chemosensitive to small changes in CO2/pH and are closely associated with large penetrating arteries. We propose that midbrain raphé neurons are sensors of blood CO2 that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis.

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JO - Nature Neuroscience

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ER -

Midbrain serotonergic neurons are central pH chemoreceptors

Abstract

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