Microstructural analysis of synergistic interactions in the control of meal size

T. H. Moran, G. J. Schwartz

Research output: Contribution to journalArticlepeer-review


Recent work in the control of ingestive behavior has focussed on the role of signals arising from peripheral sites that are stimulated by the nutrient products of ingestion. During real feeding, it is the constellation of simultaneous peripheral signals that determine short term intake. Thus, the feeding inhibitory action of CCK is enhanced in the presence of an intragastric saline load. Equivalent reductions in short term feeding over a fixed time period may result from different microstructural patterns of ingestive behavior. Differences in the microstructure of ingestion reflect differential central or peripheral processing of physiological signals. We compared patterns of ingestion in response to individual or combined meal related stimuli that reduce liquid food intake by tracking the occurrence of each lick during ingestion of a liquid test meal. Equivalent 30-min intakes are obtained following a high dose of a CCK analog alone or from a low dose in combination with a gastric saline preload. However, the patterns of licking that generate these equivalent intake volumes differ.

Original languageEnglish (US)
Pages (from-to)88-89
Number of pages2
Issue number1
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Psychology(all)
  • Nutrition and Dietetics


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