Metastatic balloon cell malignant melanoma: A case report and literature review

Lili Lee; Fang Zhou; Anthony Simms; Rosemary Wieczorek; Yanan Fang; Antonio Subietas-Mayol; Beverly Wang; Patricia Heller; Hongying Huang; Zhiheng Pei; Iman Osman; Shane Meehan; Peng Lee

Metastatic balloon cell malignant melanoma: A case report and literature review

Lili Lee, Fang Zhou, Anthony Simms, Rosemary Wieczorek, Yanan Fang, Antonio Subietas-Mayol, Beverly Wang, Patricia Heller, Hongying Huang, Zhiheng Pei, Iman Osman, Shane Meehan, Peng Lee

Pathology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A case of metastatic balloon cell malignant melanoma (BCMM) is presented. The balloon melanoma cells (BMC) were absent in the shave biopsy of the primary lesion and present as a minor component in the wide and deep excision. A subsequent right neck lymph node metastasis showed complete replacement of the lymph node by large, foamy cells. Though the tumor was amelanocytic and Fontana-Masson stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A. Ultrastructurally, the foamy cells were characterized by cytoplasmic vacuolization and a lack of melanosomes. The differential diagnosis of metastatic balloon cell malignant melanoma is broad, and clinicopathologic correlation may play a critical role in achieving the correct diagnosis.

Original language	English (US)
Pages (from-to)	315-321
Number of pages	7
Journal	International Journal of Clinical and Experimental Pathology
Volume	4
Issue number	3
State	Published - 2011

Keywords

Balloon cell
Clear cell tumors
Malignant
Melanoma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Cite this

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title = "Metastatic balloon cell malignant melanoma: A case report and literature review",

abstract = "A case of metastatic balloon cell malignant melanoma (BCMM) is presented. The balloon melanoma cells (BMC) were absent in the shave biopsy of the primary lesion and present as a minor component in the wide and deep excision. A subsequent right neck lymph node metastasis showed complete replacement of the lymph node by large, foamy cells. Though the tumor was amelanocytic and Fontana-Masson stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A. Ultrastructurally, the foamy cells were characterized by cytoplasmic vacuolization and a lack of melanosomes. The differential diagnosis of metastatic balloon cell malignant melanoma is broad, and clinicopathologic correlation may play a critical role in achieving the correct diagnosis.",

keywords = "Balloon cell, Clear cell tumors, Malignant, Melanoma",

author = "Lili Lee and Fang Zhou and Anthony Simms and Rosemary Wieczorek and Yanan Fang and Antonio Subietas-Mayol and Beverly Wang and Patricia Heller and Hongying Huang and Zhiheng Pei and Iman Osman and Shane Meehan and Peng Lee",

year = "2011",

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TY - JOUR

T1 - Metastatic balloon cell malignant melanoma

T2 - A case report and literature review

AU - Lee, Lili

AU - Zhou, Fang

AU - Simms, Anthony

AU - Wieczorek, Rosemary

AU - Fang, Yanan

AU - Subietas-Mayol, Antonio

AU - Wang, Beverly

AU - Heller, Patricia

AU - Huang, Hongying

AU - Pei, Zhiheng

AU - Osman, Iman

AU - Meehan, Shane

AU - Lee, Peng

PY - 2011

Y1 - 2011

N2 - A case of metastatic balloon cell malignant melanoma (BCMM) is presented. The balloon melanoma cells (BMC) were absent in the shave biopsy of the primary lesion and present as a minor component in the wide and deep excision. A subsequent right neck lymph node metastasis showed complete replacement of the lymph node by large, foamy cells. Though the tumor was amelanocytic and Fontana-Masson stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A. Ultrastructurally, the foamy cells were characterized by cytoplasmic vacuolization and a lack of melanosomes. The differential diagnosis of metastatic balloon cell malignant melanoma is broad, and clinicopathologic correlation may play a critical role in achieving the correct diagnosis.

AB - A case of metastatic balloon cell malignant melanoma (BCMM) is presented. The balloon melanoma cells (BMC) were absent in the shave biopsy of the primary lesion and present as a minor component in the wide and deep excision. A subsequent right neck lymph node metastasis showed complete replacement of the lymph node by large, foamy cells. Though the tumor was amelanocytic and Fontana-Masson stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A. Ultrastructurally, the foamy cells were characterized by cytoplasmic vacuolization and a lack of melanosomes. The differential diagnosis of metastatic balloon cell malignant melanoma is broad, and clinicopathologic correlation may play a critical role in achieving the correct diagnosis.

KW - Balloon cell

KW - Clear cell tumors

KW - Malignant

KW - Melanoma

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SN - 1936-2625

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JO - International Journal of Clinical and Experimental Pathology

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IS - 3

ER -

Metastatic balloon cell malignant melanoma: A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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