Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model

Sanchita P. Ghosh, Rajbir Singh, Kushal Chakraborty, Shilpa Kulkarni, Arushi Uppal, Yue Luo, Prabhjit Kaur, Rupak Pathak, K. Sree Kumar, Martin Hauer-Jensen, Amrita K. Cheema

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Exposure to ionizing radiation (IR) elicits a set of complex biological responses involving gene expression and protein turnover that ultimately manifest as dysregulation of metabolic processes representing the cellular phenotype. Although radiation biomarkers have been reported in urine and serum, they are not informative about IR mediated tissue or organ specific injury. In the present study we report IR induced metabolic changes in gastrointestinal (GI) tissue of CD2F1 mice using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry. Post-radiation GI injury is a critical determinant of survival after exposure to IR. Our results show a distinct dose and time dependent response to GI tissue injury.

Original languageEnglish (US)
Pages (from-to)723-731
Number of pages9
JournalMolecular BioSystems
Issue number4
StatePublished - Apr 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology


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