TY - JOUR
T1 - Mesenchymal Stromal Cells as Cell-Based Therapeutics for Wound Healing
AU - Malhotra, Samir
AU - Hu, Michael S.
AU - Marshall, Clement D.
AU - Leavitt, Tripp
AU - Cheung, Alexander T.M.
AU - Gonzalez, Jennifer G.
AU - Kaur, Harleen
AU - Lorenz, H. Peter
AU - Longaker, Michael T.
N1 - Funding Information:
Michael S. Hu was supported by the California Institute for Regenerative Medicine (CIRM) Clinical Fellow training grant TG2-01159. Michael S. Hu, H. Peter Lorenz, and Michael T. Longakerwere supported by theAmerican Society of Maxillofacial Surgeons (ASMS)/Maxillofacial Surgeons Foundation (MSF) Research Grant Award. H. Peter Lorenz was supported by NIH grant R01 GM087609 and a gift from Ingrid Lai and Bill Shu in honor of Anthony Shu. H. Peter Lorenz and Michael T. Longakerwere supported by theHagey Laboratory for Pediatric RegenerativeMedicine andThe Oak Foundation.
Publisher Copyright:
© 2016 Samir Malhotra et al.
PY - 2016
Y1 - 2016
N2 - Chronic wounds are a source of substantial morbidity for patients and are a major financial burden for the healthcare system. There are no current therapies that reliably improve nonhealing wounds or reverse pathological scarring. Mesenchymal stromal cells (MSCs) are a promising source of novel cell-based therapies due to the ease of their harvest and their integral role in the native wound repair process. Recent work has addressed the problems of loss of plasticity and off-target delivery through use of modern bioengineering techniques. Here we describe the applications of MSCs harvested from different sources to the wound healing process and recent advances in delivery of MSCs to targeted sites of injury.
AB - Chronic wounds are a source of substantial morbidity for patients and are a major financial burden for the healthcare system. There are no current therapies that reliably improve nonhealing wounds or reverse pathological scarring. Mesenchymal stromal cells (MSCs) are a promising source of novel cell-based therapies due to the ease of their harvest and their integral role in the native wound repair process. Recent work has addressed the problems of loss of plasticity and off-target delivery through use of modern bioengineering techniques. Here we describe the applications of MSCs harvested from different sources to the wound healing process and recent advances in delivery of MSCs to targeted sites of injury.
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U2 - 10.1155/2016/4157934
DO - 10.1155/2016/4157934
M3 - Review article
AN - SCOPUS:84959360679
SN - 1687-966X
VL - 2016
JO - Stem Cells International
JF - Stem Cells International
M1 - 4157934
ER -