Mingwei Ni, Xin Li, Ana Paula Marreilha dos Santos, Marcelo Farina, João Batista Teixeira da Rocha, Daiana S. Avila, Offie P. Soldin, Lu Rongzhu, Dejan Milatovic, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter


Methylmercury (MeHg), an organomercurial, is one of the most prevalent and toxic environmental pollutants. The major route of human exposure occurs via consumption of MeHg-adulterated seafood. Historically, MeHg epidemics in Minamata Bay, Japan, and in Iraq provided evidence of its developmental toxicity and neurological damage. This chapter describes MeHg kinetics in the human body and focuses predominantly on mechanisms involved in neuropathological and reproductive effects. The chapter also discusses the differential susceptibility to MeHg in fetuses and adults, with a special emphasis on its aberrant effects in the developing central nervous system. Discussions on risk assessment, treatment, and future directions are also covered in this chapter.

Original languageEnglish (US)
Title of host publicationReproductive and Developmental Toxicology
Number of pages13
ISBN (Electronic)9780323897730
ISBN (Print)9780323915601
StatePublished - Jan 1 2022


  • Mercury
  • Methylmercury
  • Minamata disease
  • Oxidative stress
  • Toxicity

ASJC Scopus subject areas

  • General Medicine


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