Meningeal Rosai-Dorfman disease: report of three cases and literature review.

R. Kitai, J. Llena, A. Hirano, K. Ido, K. Sato, T. Kubota

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Rosai-Dorfman disease is a well-recognized clinicopathological entity, which in rare cases affects the central nervous system, where it mimics meningioma. We describe three cases and review the literature. Histological and immunohistochemical confirmation is essential for definitive diagnosis. In addition to emperipolesis (lymphophagocytosis), reactivity for S-100 and CD68 and nonreactivity for CD-la immunostaining are characteristic features of this histioproliferative disease. In contrast to meningioma, this tumor usually occurs in young males and infiltrates the brain parenchyma.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalBrain tumor pathology
Issue number1
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research


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