Mechanisms of mitral annular calcification

Daniele Massera, Jorge R. Kizer, Marc R. Dweck

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


The mitral annulus is a fibrous structure that surrounds the mitral valve leaflets and is prone to calcification. Despite its common occurrence, association with cardiovascular morbidity and mortality and relationship with dysfunction of the mitral valve, the pathobiology of mitral annular calcification is incompletely understood. Mitral annular calcification is no longer regarded as a local, chronic and degenerative process resulting in precipitation of calcium and phosphate, but as an active and regulated molecular process that is related to lipid metabolism, hemodynamic stress, chronic kidney disease, bone and mineral metabolism and inflammation. This review summarizes the current evidence examining the pathophysiologic determinants of mitral annular calcification.

Original languageEnglish (US)
Pages (from-to)289-295
Number of pages7
JournalTrends in Cardiovascular Medicine
Issue number5
StatePublished - Jul 2020
Externally publishedYes


  • Aging
  • Mitral annular calcification
  • Valve disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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