Mechanisms of membrane transport of folates into cells and across epithelia

Rongbao Zhao, Ndeye Diop-Bove, Michele Visentin, I. David Goldman

Research output: Contribution to journalArticlepeer-review

246 Scopus citations


Until recently, the transport of folates into cells and across epithelia has been interpreted primarily within the context of two transporters with high affinity and specificity for folates, the reduced folate carrier and the folate receptors. However, there were discrepancies between the properties of these transporters and characteristics of folate transport in many tissues, most notably the intestinal absorption of folates, in terms of pH dependency and substrate specificity. With the recent cloning of the proton-coupled folate transporter (PCFT) and the demonstration that this transporter is mutated in hereditary folate malabsorption, an autosomal recessive disorder, the molecular basis for this low-pH transport activity is now understood. This review focuses on the properties of PCFT and briefly addresses the two other folate-specific transporters along with other facilitative and ATP-binding cassette (ABC) transporters with folate transport activities. The role of these transporters in the vectorial transport of folates across epithelia is considered.

Original languageEnglish (US)
Pages (from-to)177-201
Number of pages25
JournalAnnual Review of Nutrition
StatePublished - Aug 21 2011


  • Cerebral folate deficiency (CFD)
  • Heme carrier protein-1 (HCP1)
  • Hereditary folate malabsorption (HFM)
  • Intestinal folate absorption
  • Proton-coupled folate transporter (PCFT) (SLC46A1)
  • Reduced folate carrier (RFC) (SLC19A1)

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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