Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes

Aleksandra Pyziak; Agnieszka Zmyslowska; Katarzyna Bobeff; Beata Malachowska; Wojciech Fendler; Krystyna Wyka; Anna Baranowska-Jazwiecka; Malgorzata Szymanska; Agnieszka Szadkowska; Wojciech Mlynarski

doi:10.1515/jpem-2017-0100

Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes

Aleksandra Pyziak
, Agnieszka Zmyslowska
, Katarzyna Bobeff
, Beata Malachowska
, Wojciech Fendler
, Krystyna Wyka
, Anna Baranowska-Jazwiecka
, Malgorzata Szymanska
, Agnieszka Szadkowska
, Wojciech Mlynarski

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The aim of the study was to compare the selected markers in children with and without partial clinical remission (CR) of newly diagnosed type 1 diabetes (T1D). The study group consisted of 186 patients (F/M; 87/99) at onset of T1D and 24 months of follow-up. Partial CR was defined as insulin requirement <0.5 IU/kg and glycated hemoglobin (HbA_1c) <7%. Partial CR was observed in 115/186 (61.83%) of patients. At diagnosis body mass index standard deviation (BMI SDS) was higher among remitters than in non-remitters (p=0.0051) and remitters were younger (p=0.0029). In the follow-up a higher triglyceride concentration in non-remitters compared to remitters (p=0.0455) and a lower high density lipoprotein (HDL) cholesterol level (p=0.0119) were noticed. Younger age and higher BMI at diagnosis of T1D can predispose to partial CR in children. In patients with CR of T1D after 2 years of follow-up a lipid profile improvement is observed.

Original language	English (US)
Pages (from-to)	1147-1153
Number of pages	7
Journal	Journal of Pediatric Endocrinology and Metabolism
Volume	30
Issue number	11
DOIs	https://doi.org/10.1515/jpem-2017-0100
State	Published - Oct 26 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BMI
clinical remission
lipids
type 1 diabetes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1515/jpem-2017-0100

Cite this

Pyziak, A., Zmyslowska, A., Bobeff, K., Malachowska, B., Fendler, W., Wyka, K., Baranowska-Jazwiecka, A., Szymanska, M., Szadkowska, A., & Mlynarski, W. (2017). Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes. Journal of Pediatric Endocrinology and Metabolism, 30(11), 1147-1153. https://doi.org/10.1515/jpem-2017-0100

Pyziak, A, Zmyslowska, A, Bobeff, K, Malachowska, B, Fendler, W, Wyka, K, Baranowska-Jazwiecka, A, Szymanska, M, Szadkowska, A & Mlynarski, W 2017, 'Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes', Journal of Pediatric Endocrinology and Metabolism, vol. 30, no. 11, pp. 1147-1153. https://doi.org/10.1515/jpem-2017-0100

@article{88d791cae1614ab0aab5ae54f46a12b0,

title = "Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes",

abstract = "The aim of the study was to compare the selected markers in children with and without partial clinical remission (CR) of newly diagnosed type 1 diabetes (T1D). The study group consisted of 186 patients (F/M; 87/99) at onset of T1D and 24 months of follow-up. Partial CR was defined as insulin requirement <0.5 IU/kg and glycated hemoglobin (HbA1c) <7\%. Partial CR was observed in 115/186 (61.83\%) of patients. At diagnosis body mass index standard deviation (BMI SDS) was higher among remitters than in non-remitters (p=0.0051) and remitters were younger (p=0.0029). In the follow-up a higher triglyceride concentration in non-remitters compared to remitters (p=0.0455) and a lower high density lipoprotein (HDL) cholesterol level (p=0.0119) were noticed. Younger age and higher BMI at diagnosis of T1D can predispose to partial CR in children. In patients with CR of T1D after 2 years of follow-up a lipid profile improvement is observed.",

keywords = "BMI, clinical remission, lipids, type 1 diabetes",

author = "Aleksandra Pyziak and Agnieszka Zmyslowska and Katarzyna Bobeff and Beata Malachowska and Wojciech Fendler and Krystyna Wyka and Anna Baranowska-Jazwiecka and Malgorzata Szymanska and Agnieszka Szadkowska and Wojciech Mlynarski",

note = "Publisher Copyright: {\textcopyright} 2017 2017 Walter de Gruyter GmbH, Berlin/Boston.",

year = "2017",

month = oct,

day = "26",

doi = "10.1515/jpem-2017-0100",

language = "English (US)",

volume = "30",

pages = "1147--1153",

journal = "Journal of Pediatric Endocrinology and Metabolism",

issn = "0334-018X",

publisher = "Walter de Gruyter GmbH",

number = "11",

}

TY - JOUR

T1 - Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes

AU - Pyziak, Aleksandra

AU - Zmyslowska, Agnieszka

AU - Bobeff, Katarzyna

AU - Malachowska, Beata

AU - Fendler, Wojciech

AU - Wyka, Krystyna

AU - Baranowska-Jazwiecka, Anna

AU - Szymanska, Malgorzata

AU - Szadkowska, Agnieszka

AU - Mlynarski, Wojciech

PY - 2017/10/26

Y1 - 2017/10/26

N2 - The aim of the study was to compare the selected markers in children with and without partial clinical remission (CR) of newly diagnosed type 1 diabetes (T1D). The study group consisted of 186 patients (F/M; 87/99) at onset of T1D and 24 months of follow-up. Partial CR was defined as insulin requirement <0.5 IU/kg and glycated hemoglobin (HbA1c) <7%. Partial CR was observed in 115/186 (61.83%) of patients. At diagnosis body mass index standard deviation (BMI SDS) was higher among remitters than in non-remitters (p=0.0051) and remitters were younger (p=0.0029). In the follow-up a higher triglyceride concentration in non-remitters compared to remitters (p=0.0455) and a lower high density lipoprotein (HDL) cholesterol level (p=0.0119) were noticed. Younger age and higher BMI at diagnosis of T1D can predispose to partial CR in children. In patients with CR of T1D after 2 years of follow-up a lipid profile improvement is observed.

AB - The aim of the study was to compare the selected markers in children with and without partial clinical remission (CR) of newly diagnosed type 1 diabetes (T1D). The study group consisted of 186 patients (F/M; 87/99) at onset of T1D and 24 months of follow-up. Partial CR was defined as insulin requirement <0.5 IU/kg and glycated hemoglobin (HbA1c) <7%. Partial CR was observed in 115/186 (61.83%) of patients. At diagnosis body mass index standard deviation (BMI SDS) was higher among remitters than in non-remitters (p=0.0051) and remitters were younger (p=0.0029). In the follow-up a higher triglyceride concentration in non-remitters compared to remitters (p=0.0455) and a lower high density lipoprotein (HDL) cholesterol level (p=0.0119) were noticed. Younger age and higher BMI at diagnosis of T1D can predispose to partial CR in children. In patients with CR of T1D after 2 years of follow-up a lipid profile improvement is observed.

KW - BMI

KW - clinical remission

KW - lipids

KW - type 1 diabetes

UR - https://www.scopus.com/pages/publications/85033219518

UR - https://www.scopus.com/pages/publications/85033219518#tab=citedBy

U2 - 10.1515/jpem-2017-0100

DO - 10.1515/jpem-2017-0100

M3 - Article

C2 - 29016353

AN - SCOPUS:85033219518

SN - 0334-018X

VL - 30

SP - 1147

EP - 1153

JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

IS - 11

ER -

Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this