Manganese toxicity and the glutamine-glutamate cycle

Marta Sidoryk-Wegrzynowicz; Michael Aschner

doi:10.1007/978-1-4939-1932-1_30

Manganese toxicity and the glutamine-glutamate cycle

Marta Sidoryk-Wegrzynowicz, Michael Aschner

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Glutamine (Gln) is abundantly expressed in the central nervous system (CNS), where it participates in a variety of metabolic pathways. Gln metabolism proceeds via the glutamine/glutamate (Glu)-γ-aminobutyric acid (GABA) cycle (GGC), and the reactions within this cycle are carried out both in astrocytic and neuronal compartments. The GGC appears to have an important, albeit not exclusive role, in the recycling of Glu and GABA. Disruption of GGC between astrocytes and neurons contributes to changes in Glu-ergic and/or GABA-ergic transmission, and is associated with several neuropathological conditions, including manganese (Mn) toxicity.

Original language	English (US)
Title of host publication	Glutamine in Clinical Nutrition
Publisher	Springer New York
Pages	401-413
Number of pages	13
ISBN (Print)	9781493919321, 9781493919314
DOIs	https://doi.org/10.1007/978-1-4939-1932-1_30
State	Published - Jan 1 2015

Keywords

Glutamate
Glutamine
Manganese
Neurotoxicity
PKC signaling
Transporter
Ubiquitination

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Engineering(all)
Agricultural and Biological Sciences(all)

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10.1007/978-1-4939-1932-1_30

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AB - Glutamine (Gln) is abundantly expressed in the central nervous system (CNS), where it participates in a variety of metabolic pathways. Gln metabolism proceeds via the glutamine/glutamate (Glu)-γ-aminobutyric acid (GABA) cycle (GGC), and the reactions within this cycle are carried out both in astrocytic and neuronal compartments. The GGC appears to have an important, albeit not exclusive role, in the recycling of Glu and GABA. Disruption of GGC between astrocytes and neurons contributes to changes in Glu-ergic and/or GABA-ergic transmission, and is associated with several neuropathological conditions, including manganese (Mn) toxicity.

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KW - Neurotoxicity

KW - PKC signaling

KW - Transporter

KW - Ubiquitination

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BT - Glutamine in Clinical Nutrition

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Manganese toxicity and the glutamine-glutamate cycle

Abstract

Keywords

ASJC Scopus subject areas

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