Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects

Airton C. Martins; Bárbara Nunes Krum; Libânia Queirós; Alexey A. Tinkov; Anatoly V. Skalny; Aaron B. Bowman; Michael Aschner

doi:10.1021/acs.jafc.0c00641

Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects

Airton C. Martins, Bárbara Nunes Krum, Libânia Queirós, Alexey A. Tinkov, Anatoly V. Skalny, Aaron B. Bowman, Michael Aschner

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Manganese (Mn) is an essential element that participates in several biological processes. Mn serves as a cofactor for several enzymes, such as glutamine synthetase and oxidoreductases, that have an important role in the defense of the organisms against oxidative stress. The diet is the main source of Mn intake for humans, and adequate daily intake levels for this metal change with age. Moreover, in higher amounts, Mn may be toxic, mainly to the brain. Here, we provide an overview of Mn occurrence in food, addressing its bioaccessibility and discussing the dietary standard and recommended intake of Mn consumption. In addition, we review some mechanisms underlying Mn-induced neurotoxicity.

Original language	English (US)
Pages (from-to)	12893-12903
Number of pages	11
Journal	Journal of Agricultural and Food Chemistry
Volume	68
Issue number	46
DOIs	https://doi.org/10.1021/acs.jafc.0c00641
State	Published - Nov 18 2020

Keywords

essential element
manganese
neurotoxicity
nutrients
trace metal

ASJC Scopus subject areas

Chemistry(all)
Agricultural and Biological Sciences(all)

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10.1021/acs.jafc.0c00641

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title = "Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects",

abstract = "Manganese (Mn) is an essential element that participates in several biological processes. Mn serves as a cofactor for several enzymes, such as glutamine synthetase and oxidoreductases, that have an important role in the defense of the organisms against oxidative stress. The diet is the main source of Mn intake for humans, and adequate daily intake levels for this metal change with age. Moreover, in higher amounts, Mn may be toxic, mainly to the brain. Here, we provide an overview of Mn occurrence in food, addressing its bioaccessibility and discussing the dietary standard and recommended intake of Mn consumption. In addition, we review some mechanisms underlying Mn-induced neurotoxicity.",

keywords = "essential element, manganese, neurotoxicity, nutrients, trace metal",

author = "Martins, {Airton C.} and Krum, {B{\'a}rbara Nunes} and Lib{\^a}nia Queir{\'o}s and Tinkov, {Alexey A.} and Skalny, {Anatoly V.} and Bowman, {Aaron B.} and Michael Aschner",

note = "Funding Information: This work was supported by the National Institutes of Health (Grants NIEHS R01ES010563 and NIEHS R01ES020852). Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

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doi = "10.1021/acs.jafc.0c00641",

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AU - Martins, Airton C.

AU - Krum, Bárbara Nunes

AU - Queirós, Libânia

AU - Tinkov, Alexey A.

AU - Skalny, Anatoly V.

AU - Bowman, Aaron B.

AU - Aschner, Michael

PY - 2020/11/18

Y1 - 2020/11/18

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AB - Manganese (Mn) is an essential element that participates in several biological processes. Mn serves as a cofactor for several enzymes, such as glutamine synthetase and oxidoreductases, that have an important role in the defense of the organisms against oxidative stress. The diet is the main source of Mn intake for humans, and adequate daily intake levels for this metal change with age. Moreover, in higher amounts, Mn may be toxic, mainly to the brain. Here, we provide an overview of Mn occurrence in food, addressing its bioaccessibility and discussing the dietary standard and recommended intake of Mn consumption. In addition, we review some mechanisms underlying Mn-induced neurotoxicity.

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KW - neurotoxicity

KW - nutrients

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Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects

Abstract

Keywords

ASJC Scopus subject areas

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