Manganese in health and disease

Daiana Silva Avila; Robson Luiz Puntel; Michael Aschner

doi:10.1007/978-94-007-7500-8_7

Manganese in health and disease

Daiana Silva Avila, Robson Luiz Puntel, Michael Aschner

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neuro-degenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.

Original language	English (US)
Pages (from-to)	199-227
Number of pages	29
Journal	Metal Ions in Life Sciences
Volume	13
DOIs	https://doi.org/10.1007/978-94-007-7500-8_7
State	Published - 2013
Externally published	Yes

Keywords

Dopamine
Essentiality
Manganese
Manganese enzymes
Manganism
Mitochondria
Neurodegenerative diseases
Parkinson's disease-related genes
Treatment

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-94-007-7500-8_7

Cite this

@article{c2b8022ade474e5cb5d8bd53bf7fcbf8,

title = "Manganese in health and disease",

abstract = "Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neuro-degenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.",

keywords = "Dopamine, Essentiality, Manganese, Manganese enzymes, Manganism, Mitochondria, Neurodegenerative diseases, Parkinson's disease-related genes, Treatment",

author = "Avila, {Daiana Silva} and Puntel, {Robson Luiz} and Michael Aschner",

year = "2013",

doi = "10.1007/978-94-007-7500-8_7",

language = "English (US)",

volume = "13",

pages = "199--227",

journal = "Metal Ions in Life Sciences",

issn = "1559-0836",

publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - Manganese in health and disease

AU - Avila, Daiana Silva

AU - Puntel, Robson Luiz

AU - Aschner, Michael

PY - 2013

Y1 - 2013

N2 - Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neuro-degenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.

AB - Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neuro-degenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.

KW - Dopamine

KW - Essentiality

KW - Manganese

KW - Manganese enzymes

KW - Manganism

KW - Mitochondria

KW - Neurodegenerative diseases

KW - Parkinson's disease-related genes

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=84900397516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900397516&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-7500-8_7

DO - 10.1007/978-94-007-7500-8_7

M3 - Article

C2 - 24470093

AN - SCOPUS:84900397516

SN - 1559-0836

VL - 13

SP - 199

EP - 227

JO - Metal Ions in Life Sciences

JF - Metal Ions in Life Sciences

ER -

Manganese in health and disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this