Manganese in health and disease

Daiana Silva Avila, Robson Luiz Puntel, Michael Aschner

Research output: Contribution to journalArticlepeer-review

172 Scopus citations


Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neuro-degenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.

Original languageEnglish (US)
Pages (from-to)199-227
Number of pages29
JournalMetal Ions in Life Sciences
StatePublished - 2013
Externally publishedYes


  • Dopamine
  • Essentiality
  • Manganese
  • Manganese enzymes
  • Manganism
  • Mitochondria
  • Neurodegenerative diseases
  • Parkinson's disease-related genes
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)


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