Manganese exposure and induced oxidative stress in the rat brain

Keith M. Erikson, Allison W. Dobson, David C. Dorman, Michael Aschner

Research output: Contribution to journalReview articlepeer-review

134 Scopus citations


Neurotoxicity linked to excessive brain manganese levels can occur as a result of high level Mn exposures and/or metabolic aberrations (liver disease and decreased biliary excretion). Increased brain manganese levels have been reported to induce oxidative stress, as well as alterations in neurotransmitter metabolism with concurrent neurobehavioral and motor deficits. Two putative mechanisms in which manganese can produce oxidative stress in the brain are: (1) via its oxidation of dopamine, and (2) interference with normal mitochondrial respiration. Measurements of antioxidant species (e.g., glutathione and metallothionein), and the abundance of proteins (enzymes) exquisitely sensitive to oxidation (e.g., glutamine synthetase) have been commonly used as biomarkers of oxidative stress, particularly in rat brain tissue. This paper examines the link between manganese neurotoxicity in the rat brain and common pathways to oxidative stress.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalScience of the Total Environment
StatePublished - Dec 1 2004
Externally publishedYes


  • Brain
  • Glutamine synthetase
  • Glutathione
  • MMT
  • Manganese
  • Metallothionein
  • Neurotoxicity

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution


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