Manganese and Neurodegeneration

Dinamene Marques dos Santos, Michael Aschner, Ana P. Marreilha dos Santos

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Manganese (Mn; atomic no. 25, weight = 54.94 g/mol, density = 7.43 at 20°C) is a transitional metal (Group VIIa), isolated in 1774, by the Swedish chemist Scheele. Mn is the 12th most abundant element in the earth's crust, naturally present in rocks, soil, water, and food. Mn is known to be an essential trace element for animals since 1931, required for normal mammalian physiological processes, such as bone growth, development of cartilage and connective tissues, reproductive, neuronal, immune, and antioxidant functions. It can exist in 11 oxidation states from -3 to +7, being the normally encountered valences +2 (the most common form in nature), +4 (in dioxide Mn) and +7 (in permanganate ion).

Original languageEnglish (US)
Title of host publicationBiometals in Neurodegenerative Diseases
Subtitle of host publicationMechanisms and Therapeutics
PublisherElsevier Inc.
Number of pages35
ISBN (Electronic)9780128045633
ISBN (Print)9780128045626
StatePublished - Apr 28 2017


  • Biokinetics
  • Homeostatic control
  • Manganese
  • Metabolic functions
  • Neurodegeneration

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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