Manganese alters rat brain amino acids levels

Dinamene Santos, M. Camila Batoreu, Isabel Almeida, Ruben Ramos, M. Sidoryk-Wegrzynowicz, Michael Aschner, A. P. Marreilha Dos Santos

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Manganese (Mn) is an essential element and it acts as a cofactor for a number of enzymatic reactions, including those involved in amino acid, lipid, protein, and carbohydrate metabolism. Excessive exposure to Mn can lead to poisoning, characterized by psychiatric disturbances and an extrapyramidal disorder. Mn-induced neuronal degeneration is associated with alterations in amino acids metabolism. In the present study, we analyzed whole rat brain amino acid content subsequent to four or eight intraperitoneal injections, with 25 mg MnCl2/kg/day, at 48-h intervals. We noted a significant increase in glycine brain levels after four or eight Mn injections (p < 0.05 and p < 0.01, respectively) and arginine also after four or eight injections (p < 0.001). Significant increases were also noted in brain proline (p < 0.01), cysteine (p < 0.05), phenylalanine (p < 0.01), and tyrosine (p < 0.01) levels after eight Mn injections vs. the control group. These findings suggest that Mn-induced alterations in amino acid levels secondary to Mn affect the neurochemical milieu.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalBiological Trace Element Research
Issue number1-3
StatePublished - Dec 2012
Externally publishedYes


  • Amino acids
  • Brain
  • Glutamate
  • Manganese
  • Neurotoxicity
  • γ-Aminobutyric acid (GABA)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Inorganic Chemistry
  • Biochemistry, medical


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