Managing hyponatremia in cirrhosis

Elizabeth Ross, Samuel H. Sigal

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The development of hyponatremia represents an ominous event in the progression of cirrhosis to end-stage liver disease. It usually develops in those with refractory ascites and is a manifestation of the non-osmotic release of arginine vasopressin (AVP). In the hospitalized cirrhotic patient, hyponatremia is associated with increased disease severity and mortality. In this article, we review the pathophysiology of hyponatremia, its clinical implications, evaluation, and treatment.

Original languageEnglish (US)
Pages (from-to)S8-S17
JournalJournal of hospital medicine
Issue numberSUPPL. 3
StatePublished - Jul 2010
Externally publishedYes


  • Cirrhosis
  • Common electrolyte disorder
  • Hyponatremia
  • Liver failure
  • Portal hypertension

ASJC Scopus subject areas

  • Leadership and Management
  • Internal Medicine
  • Fundamentals and skills
  • Health Policy
  • Care Planning
  • Assessment and Diagnosis


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