TY - JOUR
T1 - Male sexual dysfunction associated with antiretroviral therapy
AU - Colson, Amy E.
AU - Keller, Marla J.
AU - Sax, Paul E.
AU - Pettus, Parker T.
AU - Platt, Richard
AU - Choo, Peter W.
PY - 2002/5/1
Y1 - 2002/5/1
N2 - To determine whether treatment with protease inhibitors (PIs) is associated with male sexual dysfunction, we conducted a retrospective, cohort study of 254 adult male PI recipients who received care from the staff-model division of a large managed care organization in New England between 1993 and 1998. After a median of 5.0 years of observation, 80 incident cases of sexual dysfunction were observed. Relative to unexposed individuals, the rate of sexual dysfunction adjusted for confounding was most elevated with use of ritonavir (hazard ratio [HR], 2.83; 95% confidence interval [CI], 1.34-5.97; p = .006) followed by indinavir (HR, 1.69; 95% CI, 0.84-3.37; p = .14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p = .32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p = .60). We conclude that Pis, especially ritonavir, appear to increase the risk of sexual dysfunction.
AB - To determine whether treatment with protease inhibitors (PIs) is associated with male sexual dysfunction, we conducted a retrospective, cohort study of 254 adult male PI recipients who received care from the staff-model division of a large managed care organization in New England between 1993 and 1998. After a median of 5.0 years of observation, 80 incident cases of sexual dysfunction were observed. Relative to unexposed individuals, the rate of sexual dysfunction adjusted for confounding was most elevated with use of ritonavir (hazard ratio [HR], 2.83; 95% confidence interval [CI], 1.34-5.97; p = .006) followed by indinavir (HR, 1.69; 95% CI, 0.84-3.37; p = .14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p = .32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p = .60). We conclude that Pis, especially ritonavir, appear to increase the risk of sexual dysfunction.
KW - Adverse drug effects
KW - Antiretroviral therapy
KW - Protease inhibitors
KW - Sexual dysfunction Pharmacoepidemiology
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U2 - 10.1097/00042560-200205010-00004
DO - 10.1097/00042560-200205010-00004
M3 - Article
C2 - 12048360
AN - SCOPUS:0036570558
SN - 1525-4135
VL - 30
SP - 27
EP - 32
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
IS - 1
ER -
