Major depressive disorder with anger attacks and cardiovascular risk factors

Renerio Fraguas, Dan V. Iosifescu, Bettina Bankier, Roy Perlis, Nicoletta Clementi-Craven, Jonathan Alpert, Maurizio Fava

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Objective: Depression and anger have been separately associated with cardiovascular risk factors. We investigated if major depressive disorder (MDD) with concomitant anger attacks was associated with cardiovascular risk factors. Method: We measured total serum cholesterol, glycemia, resting blood pressure, and smoking parameters in 333 (52.9% women) MDD nonpsychotic outpatients, mean age of 39.4 years. MDD was diagnosed with the Structured Clinical Interview (SClD) in accordance with the Diagnostic and Statistic Manual of Mental Disorders, Third Edition, Revised (DSM-III-R). The presence of anger attacks was established with the Massachusetts General Hospital Anger Attacks Questionnaire. Results: In a logistic regression analysis, anger attacks were independently associated with cholesterol levels ≥ 200mg/dL (odds ratio [OR], 2.16; 95% confidence interval [CI], 1.18-3.94) and years of smoking >11 (OR, 2.59; 95%CI, 1.32-5.04). Conclusions: MDD with anger attacks was significantly associated with increased cholesterol levels and years of smoking.

Original languageEnglish (US)
Pages (from-to)99-111
Number of pages13
JournalInternational Journal of Psychiatry in Medicine
Issue number1
StatePublished - 2007
Externally publishedYes


  • Anger
  • Cardiovascular
  • Cholesterol
  • Depression
  • Hostility
  • Irritability
  • Risk factors
  • Smoking

ASJC Scopus subject areas

  • Psychiatry and Mental health


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