TY - JOUR
T1 - Magnetic resonance imaging in experimental Chagas disease
T2 - A brief review of the utility of the method for monitoring right ventricular chamber dilatation
AU - De Souza, Andréa P.
AU - Tang, Baiyu
AU - Tanowitz, Herbert B.
AU - Araújo-Jorge, Tania C.
AU - Jelicks, E. Linda A.
N1 - Funding Information:
* p < 0.05 as compared to controls (day 0); ** p < 0.05 as compared to infected mice at the acute phase; *** p < 0.05 as compared to infected mice at the acute and chronic phases; **** p < 0.05 as compared to infected mice at the chronic phase a Adapted and completed by Jelicks et al. (1999). The dimensions of the cardiac chambers are expressed in millimeter (mean ± SEM). Non-parametric analysis (Kruskal–Wallis). dpi days postinfection, RVID inner dimension of right ventricle, LVID inner dimension of left ventricle, LVWall left ventricle wall Acknowledgments We are grateful to Dr. Solange Lisboa de Castro for reviewing this paper. This work was supported with grants from NIH, Fiocruz, Faperj, CNPq and CAPES, and was performed in accordance with the guidelines established by the Institutional Animal Use Committee.
PY - 2005/8
Y1 - 2005/8
N2 - Chagas' disease caused by infection with Trypanosoma cruzi leads to a myocardiopathy that evolves from the acute to the chronic phase. Magnetic resonance imaging (MRI) is an important tool for monitoring cardiac morphology and function both in humans and in animals. In the present work, we present a brief review of MRI applications for the study of ventricular hypertrophy and dilatation of the right ventricle in murine models of Chagas' disease. Studies using MRI demonstrate an increase in right ventricular chamber dimension during both phases of infection, indicating that increase of the right ventricle is a marker for experimental chagasic myocardiopathy. Based on previous studies using MRI in these models we propose that this technique is an excellent approach for monitoring heart functionality from the acute through the chronic phase of infection in different parasite-host pairs and for monitoring the efficacy of cardioprotective or immune-therapeutic agents.
AB - Chagas' disease caused by infection with Trypanosoma cruzi leads to a myocardiopathy that evolves from the acute to the chronic phase. Magnetic resonance imaging (MRI) is an important tool for monitoring cardiac morphology and function both in humans and in animals. In the present work, we present a brief review of MRI applications for the study of ventricular hypertrophy and dilatation of the right ventricle in murine models of Chagas' disease. Studies using MRI demonstrate an increase in right ventricular chamber dimension during both phases of infection, indicating that increase of the right ventricle is a marker for experimental chagasic myocardiopathy. Based on previous studies using MRI in these models we propose that this technique is an excellent approach for monitoring heart functionality from the acute through the chronic phase of infection in different parasite-host pairs and for monitoring the efficacy of cardioprotective or immune-therapeutic agents.
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U2 - 10.1007/s00436-005-1409-4
DO - 10.1007/s00436-005-1409-4
M3 - Review article
C2 - 15986245
AN - SCOPUS:24044451232
SN - 0932-0113
VL - 97
SP - 87
EP - 90
JO - Parasitology research
JF - Parasitology research
IS - 2
ER -
