Macrophages and control of granulomatous inflammation in tuberculosis

J. L. Flynn; J. Chan; P. L. Lin

doi:10.1038/mi.2011.14

Macrophages and control of granulomatous inflammation in tuberculosis

J. L. Flynn, J. Chan, P. L. Lin

Research output: Contribution to journal › Review article › peer-review

262 Scopus citations

Abstract

The granuloma that forms in response to Mycobacterium tuberculosis must be carefully balanced in terms of immune responses to provide sufficient immune cell activation to inhibit the growth of the bacilli, yet modulate the inflammation to prevent pathology. There are likely many scenarios by which this balance can be reached, given the complexity of the immune responses induced by M. tuberculosis. In this review, we focus on the key role of the macrophage in balancing inflammation in the granuloma.

Original language	English (US)
Pages (from-to)	271-278
Number of pages	8
Journal	Mucosal Immunology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1038/mi.2011.14
State	Published - May 2011
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/mi.2011.14

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title = "Macrophages and control of granulomatous inflammation in tuberculosis",

abstract = "The granuloma that forms in response to Mycobacterium tuberculosis must be carefully balanced in terms of immune responses to provide sufficient immune cell activation to inhibit the growth of the bacilli, yet modulate the inflammation to prevent pathology. There are likely many scenarios by which this balance can be reached, given the complexity of the immune responses induced by M. tuberculosis. In this review, we focus on the key role of the macrophage in balancing inflammation in the granuloma.",

author = "Flynn, {J. L.} and J. Chan and Lin, {P. L.}",

note = "Funding Information: We acknowledge support from the NIH (J.L.F.: AI37859, HL092883; J.L.F. and J.C.: AI50732, HL71241) and the Bill and Melinda Gates Foundation (J.L.F. and P.L.L.).",

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AU - Chan, J.

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N2 - The granuloma that forms in response to Mycobacterium tuberculosis must be carefully balanced in terms of immune responses to provide sufficient immune cell activation to inhibit the growth of the bacilli, yet modulate the inflammation to prevent pathology. There are likely many scenarios by which this balance can be reached, given the complexity of the immune responses induced by M. tuberculosis. In this review, we focus on the key role of the macrophage in balancing inflammation in the granuloma.

AB - The granuloma that forms in response to Mycobacterium tuberculosis must be carefully balanced in terms of immune responses to provide sufficient immune cell activation to inhibit the growth of the bacilli, yet modulate the inflammation to prevent pathology. There are likely many scenarios by which this balance can be reached, given the complexity of the immune responses induced by M. tuberculosis. In this review, we focus on the key role of the macrophage in balancing inflammation in the granuloma.

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Macrophages and control of granulomatous inflammation in tuberculosis

Abstract

ASJC Scopus subject areas

UN SDGs

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