TY - JOUR
T1 - m-Chlorophenylpiperazine challenge in borderline personality disorder
T2 - Relationship of neuroendocrine response, behavioral response, and clinical measures
AU - Stein, Dan J.
AU - Hollander, Eric
AU - DeCaria, Concetta M.
AU - Simeon, Daphne
AU - Cohen, Lisa
AU - Aronowitz, Bonnie
PY - 1996/9/15
Y1 - 1996/9/15
N2 - We have previously found that a subgroup of patients with impulsive personality disorders respond to m-chlorophenylpiperazine (m-CPP) administration with a distinctive spacy/high behavioral reaction and with increased cortisol responses. In this report we analyzed the relationship between behavioral and neuroendocrine responses to m-CPP in an enlarged sample of patients with borderline personality disorder (BPD), We also assessed the association of behavioral and neuroendocrine responses with clinical symptoms and with m-CPP blood levels. We found that in BPD patients the presence of a spacy/high behavioral response was significantly associated with increased prolactin and cortisol responses to m-CPP. In BPD patients increased m-CPP levels were significantly associated with neuroendocrine hypersensitivity and with a spacy/high behavioral response, while in controls increased m-CPP levels were not significantly associated with neuroendocrine hypersensitivity but were significantly associated with dysphoric behavioral responses. Taken together with previous work on m-CPP in obsessive-compulsive disorder, these results are partially consistent with the hypothesis that compulsive and impulsive symptoms fall at opposite ends of a phenomenologic and neurobiologic spectrum.
AB - We have previously found that a subgroup of patients with impulsive personality disorders respond to m-chlorophenylpiperazine (m-CPP) administration with a distinctive spacy/high behavioral reaction and with increased cortisol responses. In this report we analyzed the relationship between behavioral and neuroendocrine responses to m-CPP in an enlarged sample of patients with borderline personality disorder (BPD), We also assessed the association of behavioral and neuroendocrine responses with clinical symptoms and with m-CPP blood levels. We found that in BPD patients the presence of a spacy/high behavioral response was significantly associated with increased prolactin and cortisol responses to m-CPP. In BPD patients increased m-CPP levels were significantly associated with neuroendocrine hypersensitivity and with a spacy/high behavioral response, while in controls increased m-CPP levels were not significantly associated with neuroendocrine hypersensitivity but were significantly associated with dysphoric behavioral responses. Taken together with previous work on m-CPP in obsessive-compulsive disorder, these results are partially consistent with the hypothesis that compulsive and impulsive symptoms fall at opposite ends of a phenomenologic and neurobiologic spectrum.
KW - Borderline personality disorder
KW - Compulsivity
KW - Impulsivity
KW - Obsessive-compulsive disorder
KW - Serotonin
KW - m-chlorophenylpiperazine
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U2 - 10.1016/0006-3223(95)00470-X
DO - 10.1016/0006-3223(95)00470-X
M3 - Article
C2 - 8879471
AN - SCOPUS:0030587418
SN - 0006-3223
VL - 40
SP - 508
EP - 513
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 6
ER -