@article{0136826932cb452a9450ab50506be3a7,
title = "Longitudinal assessment of systemic and genital tract inflammatory markers and endogenous genital tract E. Coli inhibitory activity in HIV-infected and uninfected women",
abstract = "Problem Stability over time of systemic and mucosal immunity and their associations with bacterial vaginosis (BV) and HIV-specific parameters were assessed. Method of Study Immune mediators and HIV viral load in plasma and cervicovaginal lavage (CVL), E. coli inhibition, and Nugent score were measured at three semiannual visits among 94 participants in the Women{\textquoteright}s Interagency HIV Study. Mixed models identified the factors associated with immune mediators. Results There was higher E. coli inhibition and lower inflammation over time in the genital tract and systemically. BV was consistently associated with higher CVL inflammatory mediators and lower CVL E. coli inhibition. HIV-infected women with higher CD4 counts had lower systemic and genital inflammatory mediators, and genital HIV shedding was associated with higher CVL inflammatory mediators. Use of antiretroviral therapy (ART) was associated with lower plasma and CVL mediators, but higher E. coli inhibition. Conclusion HIV and BV are linked to inflammation, and ART may be associated with improved vaginal health.",
keywords = "Bacterial vaginosis, Genital tract, HIV, Inflammation, Mucosal immunity",
author = "Keller, {Marla J.} and McGinn, {Aileen P.} and Yungtai Lo and Ashley Huber and Lilia Espinoza and Howard Minkoff and Christine Colie and Nowicki, {Marek J.} and Gypsyamber D{\textquoteright}Souza and Kathryn Anastos",
note = "Funding Information: This study was supported in part by Grants UL1 TR001073 (Einstein CTSA) and P30 AI-51519 (Einstein CFAR). Funding Information: This study was supported in part by Grants UL1 TR001073 (Einstein CTSA) and P30 AI-51519 (Einstein CFAR). Data in this manuscript were collected by the Women{\textquoteright}s Interagency HIV Study (WIHS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). WIHS (principal investigators): Bronx WIHS (Kathryn Anastos), U01-AI-035004; Brooklyn WIHS (Howard Minkoff and Deborah Gustafson), U01-AI-031834; Metropolitan Washington WIHS (Mary Young), U01-AI-034994; WIHS Data Management and Analysis Center (Stephen Gange and Elizabeth Golub), U01-AI-042590; Southern California WIHS (Alexandra Levine and Marek Nowicki), U01-HD-032632 (WIHS I-WIHS IV). The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute on Mental Health (NIMH). Targeted supplemental funding for specific projects is also provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute on Deafness and other Communication Disorders (NIDCD), and the NIH Office of Research on Women{\textquoteright}s Health. Funding Information: Data in this manuscript were collected by the Women{\textquoteright}s Interagency HIV Study (WIHS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). WIHS (principal investigators): Bronx WIHS (Kathryn Anastos), U01-AI-035004; Brooklyn WIHS (Howard Minkoff and Deborah Gustafson), U01-AI-031834; Metropolitan Washington WIHS (Mary Young), U01-AI-034994; WIHS Data Management and Analysis Center (Stephen Gange and Elizabeth Golub), U01-AI-042590; Southern California WIHS (Alexandra Levine and Marek Nowicki), U01-HD-032632 (WIHS I–WIHS IV). The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute on Mental Health (NIMH). Targeted supplemental funding for specific projects is also provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute on Deafness and other Communication Disorders (NIDCD), and the NIH Office of Research on Women{\textquoteright}s Health. Publisher Copyright: {\textcopyright} 2016 John Wiley & Sons A/S.",
year = "2016",
doi = "10.1111/aji.12518",
language = "English (US)",
volume = "75",
pages = "631--642",
journal = "American Journal of Reproductive Immunology",
issn = "1046-7408",
number = "6",
}
