Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis

Vasan K. Sambandamurthy; Steven C. Derrick; Kripa V. Jalapathy; Bing Chen; Robert G. Russell; Sheldon L. Morris; William R. Jacobs

doi:10.1128/IAI.73.2.1196-1203.2005

Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis

Vasan K. Sambandamurthy
, Steven C. Derrick
, Kripa V. Jalapathy
, Bing Chen
, Robert G. Russell
, Sheldon L. Morris
, William R. Jacobs

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.

Original language	English (US)
Pages (from-to)	1196-1203
Number of pages	8
Journal	Infection and immunity
Volume	73
Issue number	2
DOIs	https://doi.org/10.1128/IAI.73.2.1196-1203.2005
State	Published - Feb 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.73.2.1196-1203.2005

Cite this

Sambandamurthy, V. K., Derrick, S. C., Jalapathy, K. V., Chen, B., Russell, R. G., Morris, S. L., & Jacobs, W. R. (2005). Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis. Infection and immunity, 73(2), 1196-1203. https://doi.org/10.1128/IAI.73.2.1196-1203.2005

Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis. / Sambandamurthy, Vasan K.; Derrick, Steven C.; Jalapathy, Kripa V. et al.
In: Infection and immunity, Vol. 73, No. 2, 02.2005, p. 1196-1203.

Research output: Contribution to journal › Article › peer-review

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Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis

Abstract

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