Liver-targeted regenerative medicine

Naoya Kobayashi, Chen Yong, Noriaki Tanaka

Research output: Contribution to journalReview articlepeer-review


Recently, much attention has been drawn to liver-targeted regenerative medicine for the treatment of liver failure. Researchers in various fields consider that the following cells can be used for such therapy: human embryonic stem (ES) cells, somatic stem cells, hepatic stem cells, small hepatocytes, bone marrow- and cord blood-derived hepatic progenitor cells, and human hepatocyte cell lines. The Cre/loxP-based reversible immortalization of human hepatocytes is also introduced in this review article. Here we describe the candidates that can contribute to hepatic regeneration. This reversible immortalization system allows us to establish a highly safe human hepatocyte line that is capable of differentiation at a lower cost and on a larger scale.

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalNippon Geka Gakkai zasshi
Issue number8
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Medicine(all)


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