Liver Failure after Hydroxycut™ Use in a Patient with Undiagnosed Hereditary Coproporphyria

Stephanie Haimowitz, Jennifer Hsieh, Marina Shcherba, Yelena Averbukh

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We report the case of a young male presenting with cholestatic liver failure. After an extensive workup, the etiology of the liver failure was determined to be due to hereditary coprophorphyria (HCP). The inciting event was the use of Hydroxycut™, an over-the-counter supplement to promote weight loss that has been reported to cause oxidative liver injury in vulnerable populations. Although HCP is a rare cause of cholestatic liver failure, it is treatable if diagnosed correctly and in a timely manner. In this clinical vignette, we discuss a case that highlights the genetic susceptibility to disease that can be unmasked by environmental exposures. We also review the relevant literature on Hydroxycut™ and how it can affect hepatic function.

Original languageEnglish (US)
Pages (from-to)856-859
Number of pages4
JournalJournal of general internal medicine
Issue number6
StatePublished - Jun 26 2015
Externally publishedYes


  • herbal supplement use
  • liver failure
  • porphyria

ASJC Scopus subject areas

  • Internal Medicine


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