TY - CHAP
T1 - Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles
AU - Zamith-Miranda, Daniel
AU - Alves, Lysangela Ronalte
AU - Nakayasu, Ernesto Satoshi
AU - Nosanchuk, Joshua Daniel
N1 - Publisher Copyright:
© 2021, Springer Nature Switzerland AG.
PY - 2021
Y1 - 2021
N2 - Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.
AB - Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.
KW - Extracellular vesicles
KW - Histoplasma capsulatum
KW - Proteomics
KW - Serology
UR - http://www.scopus.com/inward/record.url?scp=85123036713&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123036713&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-83391-6_2
DO - 10.1007/978-3-030-83391-6_2
M3 - Chapter
C2 - 34972874
AN - SCOPUS:85123036713
T3 - Current Topics in Microbiology and Immunology
SP - 13
EP - 18
BT - Current Topics in Microbiology and Immunology
PB - Springer Science and Business Media Deutschland GmbH
ER -