Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles

Daniel Zamith-Miranda; Lysangela Ronalte Alves; Ernesto Satoshi Nakayasu; Joshua Daniel Nosanchuk

doi:10.1007/978-3-030-83391-6_2

Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles

Daniel Zamith-Miranda, Lysangela Ronalte Alves, Ernesto Satoshi Nakayasu, Joshua Daniel Nosanchuk

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.

Original language	English (US)
Title of host publication	Current Topics in Microbiology and Immunology
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	13-18
Number of pages	6
DOIs	https://doi.org/10.1007/978-3-030-83391-6_2
State	Published - 2021

Publication series

Name	Current Topics in Microbiology and Immunology
Volume	432
ISSN (Print)	0070-217X
ISSN (Electronic)	2196-9965

Keywords

Extracellular vesicles
Histoplasma capsulatum
Proteomics
Serology

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

Access to Document

10.1007/978-3-030-83391-6_2

Cite this

Zamith-Miranda, D., Alves, L. R., Nakayasu, E. S., & Nosanchuk, J. D. (2021). Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles. In Current Topics in Microbiology and Immunology (pp. 13-18). (Current Topics in Microbiology and Immunology; Vol. 432). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-83391-6_2

Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles. / Zamith-Miranda, Daniel; Alves, Lysangela Ronalte; Nakayasu, Ernesto Satoshi et al.
Current Topics in Microbiology and Immunology. Springer Science and Business Media Deutschland GmbH, 2021. p. 13-18 (Current Topics in Microbiology and Immunology; Vol. 432).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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abstract = "Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.",

keywords = "Extracellular vesicles, Histoplasma capsulatum, Proteomics, Serology",

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note = "Funding Information: Acknowledgement J.D.N., E.S.N., and D.Z-M were supported in part by NIH R21AI124797. LRA received financial support from Inova Fiocruz/Funda{\c c}{\~a}o Oswaldo Cruz [Grant number VPPCB-07-FIO-18-2-52] and CNPq [Grant number 442317/2019-0]. L.R.A is a research fellow awardee from CNPq. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.",

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AB - Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.

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KW - Serology

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Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles

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