TY - JOUR
T1 - LAPping up dead cells to prevent lupus nephritis
T2 - a novel role for noncanonical autophagy in autoimmunity
AU - Leventhal, Jeremy S.
AU - Ross, Michael J.
N1 - Publisher Copyright:
© 2016
PY - 2016/8/1
Y1 - 2016/8/1
N2 - The mechanisms underlying the development of systemic lupus erythematosus and lupus nephritis remain poorly understood. A recent study demonstrates that deficiencies in the immune system's ability to degrade scavenged dead cells via noncanonical autophagy is sufficient to break immune tolerance and produce features commonly seen in lupus, including circulating autoantibodies, inflammatory cytokines, and nephritis. This work provides a possible mechanism for the association of polymorphisms in autophagy genes with the risk of lupus.
AB - The mechanisms underlying the development of systemic lupus erythematosus and lupus nephritis remain poorly understood. A recent study demonstrates that deficiencies in the immune system's ability to degrade scavenged dead cells via noncanonical autophagy is sufficient to break immune tolerance and produce features commonly seen in lupus, including circulating autoantibodies, inflammatory cytokines, and nephritis. This work provides a possible mechanism for the association of polymorphisms in autophagy genes with the risk of lupus.
UR - http://www.scopus.com/inward/record.url?scp=84992482209&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992482209&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2016.06.001
DO - 10.1016/j.kint.2016.06.001
M3 - Comment/debate
C2 - 27418084
AN - SCOPUS:84992482209
SN - 0085-2538
VL - 90
SP - 238
EP - 239
JO - Kidney international
JF - Kidney international
IS - 2
ER -