L-Dihydroxyphenylalanine induces melanin production by members of the genus Trichosporon

Maria Helena Galdino Figueiredo-Carvalho; Fábio B. dos Santos; Joshua D. Nosanchuk; Rosely M. Zancope-Oliveira; Rodrigo Almeida-Paes

doi:10.1111/1567-1364.12174

L-Dihydroxyphenylalanine induces melanin production by members of the genus Trichosporon

Maria Helena Galdino Figueiredo-Carvalho, Fábio B. dos Santos, Joshua D. Nosanchuk, Rosely M. Zancope-Oliveira, Rodrigo Almeida-Paes

Medicine

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13 Scopus citations

Abstract

Melanization of members of the genus Trichosporon is poorly described. In this study, six strains, including two clinical isolates, from four different species (Trichosporon asahii, T. asteroides, T. inkin, and T. mucoides) were grown in culture media with or without L-dihydroxyphenylalanine (L-DOPA). Each strain produced a brownish pigment compatible with melanin when cultured in presence of L-DOPA, suggesting that these species are able to produce eumelanin. L-tyrosine was not able to elicit any type of pigment production on cultures. As eumelanin is produced by several fungi during parasitism, this pigment may contribute to Trichosporon virulence.

Original language	English (US)
Pages (from-to)	988-991
Number of pages	4
Journal	FEMS Yeast Research
Volume	14
Issue number	6
DOIs	https://doi.org/10.1111/1567-1364.12174
State	Published - 2014

Keywords

L-DOPA
Melanin
Trichosporon

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology

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10.1111/1567-1364.12174

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title = "L-Dihydroxyphenylalanine induces melanin production by members of the genus Trichosporon",

abstract = "Melanization of members of the genus Trichosporon is poorly described. In this study, six strains, including two clinical isolates, from four different species (Trichosporon asahii, T. asteroides, T. inkin, and T. mucoides) were grown in culture media with or without L-dihydroxyphenylalanine (L-DOPA). Each strain produced a brownish pigment compatible with melanin when cultured in presence of L-DOPA, suggesting that these species are able to produce eumelanin. L-tyrosine was not able to elicit any type of pigment production on cultures. As eumelanin is produced by several fungi during parasitism, this pigment may contribute to Trichosporon virulence.",

keywords = "L-DOPA, Melanin, Trichosporon",

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T1 - L-Dihydroxyphenylalanine induces melanin production by members of the genus Trichosporon

AU - Figueiredo-Carvalho, Maria Helena Galdino

AU - dos Santos, Fábio B.

AU - Nosanchuk, Joshua D.

AU - Zancope-Oliveira, Rosely M.

AU - Almeida-Paes, Rodrigo

PY - 2014

Y1 - 2014

N2 - Melanization of members of the genus Trichosporon is poorly described. In this study, six strains, including two clinical isolates, from four different species (Trichosporon asahii, T. asteroides, T. inkin, and T. mucoides) were grown in culture media with or without L-dihydroxyphenylalanine (L-DOPA). Each strain produced a brownish pigment compatible with melanin when cultured in presence of L-DOPA, suggesting that these species are able to produce eumelanin. L-tyrosine was not able to elicit any type of pigment production on cultures. As eumelanin is produced by several fungi during parasitism, this pigment may contribute to Trichosporon virulence.

AB - Melanization of members of the genus Trichosporon is poorly described. In this study, six strains, including two clinical isolates, from four different species (Trichosporon asahii, T. asteroides, T. inkin, and T. mucoides) were grown in culture media with or without L-dihydroxyphenylalanine (L-DOPA). Each strain produced a brownish pigment compatible with melanin when cultured in presence of L-DOPA, suggesting that these species are able to produce eumelanin. L-tyrosine was not able to elicit any type of pigment production on cultures. As eumelanin is produced by several fungi during parasitism, this pigment may contribute to Trichosporon virulence.

KW - L-DOPA

KW - Melanin

KW - Trichosporon

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L-Dihydroxyphenylalanine induces melanin production by members of the genus Trichosporon

Abstract

Keywords

ASJC Scopus subject areas

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