@article{70861d63eddf4f6ab0e5f38e6ec160f7,
title = "L-arginine and covid-19: An update",
abstract = "L-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.",
keywords = "Antiviral therapies, Arginine, COVID-19, Coronavirus, Cytokine storm, Endothelium, Immune response, Immunity, Inflammation, Nitric oxide, Nitrosylation, Oxidative stress, ROS, SARS-CoV-2, T cells, Viral infections",
author = "Ayobami Adebayo and Fahimeh Varzideh and Scott Wilson and Jessica Gambardella and Michael Eacobacci and Jankauskas, {Stanislovas S.} and Kwame Donkor and Urna Kansakar and Valentina Trimarco and Pasquale Mone and Angela Lombardi and Gaetano Santulli",
note = "Funding Information: Funding: The Santulli{\textquoteright}s Lab is supported in part by the National Institutes of Health (NIH: R01-HL146691, R01-DK123259, R01-HL159062, R01-DK033823, R56-AG066431, T32-HL144456, and R00-DK107895, to G.S.), by the Irma T. Hirschl and Monique Weill-Caulier Trusts (to G.S.), by the Diabetes Action Research and Education Foundation (to G.S.), and by the American Heart Association (AHA-21POST836407 to S.S.J. and AHA-20POST35211151 to J.G.). Publisher Copyright: {\textcopyright} 2021 by the authors.Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = nov,
doi = "10.3390/nu13113951",
language = "English (US)",
volume = "13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",
}