L-arginine and covid-19: An update

Ayobami Adebayo, Fahimeh Varzideh, Scott Wilson, Jessica Gambardella, Michael Eacobacci, Stanislovas S. Jankauskas, Kwame Donkor, Urna Kansakar, Valentina Trimarco, Pasquale Mone, Angela Lombardi, Gaetano Santulli

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


L-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.

Original languageEnglish (US)
Article number3951
Issue number11
StatePublished - Nov 2021


  • Antiviral therapies
  • Arginine
  • COVID-19
  • Coronavirus
  • Cytokine storm
  • Endothelium
  • Immune response
  • Immunity
  • Inflammation
  • Nitric oxide
  • Nitrosylation
  • Oxidative stress
  • ROS
  • SARS-CoV-2
  • T cells
  • Viral infections

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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