TY - JOUR
T1 - Kuru-Like Neuropathological Changes in a North American
AU - Horoupian, Dikran S.
AU - Powers, James M.
AU - Schaumburg, Herbert H.
PY - 1972/12
Y1 - 1972/12
N2 - Kuru is a fatal progressive disease of the central nervous system with clinical manifestations of ataxia, dementia, and myoclonus. So far, kuru and Creutzfeldt-Jakob disease (C-J) are the only two forms of transmissible subacute spongiform viral encephalopathy known to affect humans. All of the reported cases of kuru have occurred in a restricted area of New Guinea, while Creutzfeldt-Jakob has had a wide distribution. We have examined postmortem tissue from a 54-year-old Jamaican woman with an 11-month progressive ataxic and dementing illness, clinically diagnosed as the ataxic form of C-J. Light and electron microscopic examination of the brain showed the distribution and changes described in kuru, including the presence of numerous PAS-positive kuru plaques in the cerebellum.
AB - Kuru is a fatal progressive disease of the central nervous system with clinical manifestations of ataxia, dementia, and myoclonus. So far, kuru and Creutzfeldt-Jakob disease (C-J) are the only two forms of transmissible subacute spongiform viral encephalopathy known to affect humans. All of the reported cases of kuru have occurred in a restricted area of New Guinea, while Creutzfeldt-Jakob has had a wide distribution. We have examined postmortem tissue from a 54-year-old Jamaican woman with an 11-month progressive ataxic and dementing illness, clinically diagnosed as the ataxic form of C-J. Light and electron microscopic examination of the brain showed the distribution and changes described in kuru, including the presence of numerous PAS-positive kuru plaques in the cerebellum.
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U2 - 10.1001/archneur.1972.00490180091018
DO - 10.1001/archneur.1972.00490180091018
M3 - Article
C2 - 5083870
AN - SCOPUS:0015475527
SN - 0003-9942
VL - 27
SP - 555
EP - 561
JO - Archives of Neurology
JF - Archives of Neurology
IS - 6
ER -