Knotted proteins

Olesya V. Stepanenko, G. S. Bublikov, Olga V. Stepanenko, G. N. Rychkov, O. I. Povarova, V. V. Verkhusha, K. K. Turoverov, I. M. Kuznetsova

Research output: Contribution to journalReview articlepeer-review


For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
Issue number3
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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