InVivo thermal ablation monitoring using ultrasound echo decorrelation imaging

Swetha Subramanian, Steven M. Rudich, Amel Alqadah, Chandra Priya Karunakaran, Marepalli B. Rao, T. Douglas Mast

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Previous work indicated that ultrasound echo decorrelation imaging can track and quantify changes in echo signals to predict thermal damage during invitro radiofrequency ablation (RFA). In the invivo studies reported here, the feasibility of using echo decorrelation imaging as a treatment monitoring tool was assessed. RFA was performed on normal swine liver (N= 5), and ultrasound ablation using image-ablate arrays was performed on rabbit liver implanted with VX2 tumors (N= 2). Echo decorrelation and integrated backscatter were computed from Hilbert transformed pulse-echo data acquired during RFA and ultrasound ablation treatments. Receiver operating characteristic (ROC) curves were employed to assess the ability of echo decorrelation imaging and integrated backscatter to predict ablation. Area under the ROC curves (AUROC) was determined for RFA and ultrasound ablation using echo decorrelation imaging. Ablation was predicted more accurately using echo decorrelation imaging (AUROC= 0.832 and 0.776 for RFA and ultrasound ablation, respectively) than using integrated backscatter (AUROC= 0.734 and 0.494).

Original languageEnglish (US)
Pages (from-to)102-114
Number of pages13
JournalUltrasound in Medicine and Biology
Issue number1
StatePublished - Jan 2014
Externally publishedYes


  • Bulk ultrasound ablation
  • Echo decorrelation imaging
  • Radiofrequency ablation
  • Therapy monitoring

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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