Invariant NKT cell regulation of autoimmunity

Alberto Molano; Steven A. Porcelli

doi:10.1016/j.ddmec.2006.05.002

Invariant NKT cell regulation of autoimmunity

Alberto Molano
, Steven A. Porcelli

Microbiology & Immunology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Accumulating evidence supports the notion that invariant NKT cells that recognize glycolipids presented by CD1d can play a role in the regulation of certain types of autoimmunity. Focusing mainly on studies of type 1 diabetes and several other common autoimmune diseases, we present an overview of the available knowledge and current speculations on the immunoregulatory mechanisms of NKT cells. Targeting invariant NKT cells with specific glycolipids that bind to CD1d might prove to be a powerful means of modulating autoimmunity.

Original language	English (US)
Pages (from-to)	193-198
Number of pages	6
Journal	Drug Discovery Today: Disease Mechanisms
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.ddmec.2006.05.002
State	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1016/j.ddmec.2006.05.002

Cite this

@article{f672f204048b4eaa9cd581ef6c69a99c,

title = "Invariant NKT cell regulation of autoimmunity",

abstract = "Accumulating evidence supports the notion that invariant NKT cells that recognize glycolipids presented by CD1d can play a role in the regulation of certain types of autoimmunity. Focusing mainly on studies of type 1 diabetes and several other common autoimmune diseases, we present an overview of the available knowledge and current speculations on the immunoregulatory mechanisms of NKT cells. Targeting invariant NKT cells with specific glycolipids that bind to CD1d might prove to be a powerful means of modulating autoimmunity.",

author = "Alberto Molano and Porcelli, \{Steven A.\}",

year = "2006",

doi = "10.1016/j.ddmec.2006.05.002",

language = "English (US)",

volume = "3",

pages = "193--198",

journal = "Drug Discovery Today: Disease Mechanisms",

issn = "1740-6765",

publisher = "Elsevier Ltd",

number = "2",

}

TY - JOUR

T1 - Invariant NKT cell regulation of autoimmunity

AU - Molano, Alberto

AU - Porcelli, Steven A.

PY - 2006

Y1 - 2006

N2 - Accumulating evidence supports the notion that invariant NKT cells that recognize glycolipids presented by CD1d can play a role in the regulation of certain types of autoimmunity. Focusing mainly on studies of type 1 diabetes and several other common autoimmune diseases, we present an overview of the available knowledge and current speculations on the immunoregulatory mechanisms of NKT cells. Targeting invariant NKT cells with specific glycolipids that bind to CD1d might prove to be a powerful means of modulating autoimmunity.

AB - Accumulating evidence supports the notion that invariant NKT cells that recognize glycolipids presented by CD1d can play a role in the regulation of certain types of autoimmunity. Focusing mainly on studies of type 1 diabetes and several other common autoimmune diseases, we present an overview of the available knowledge and current speculations on the immunoregulatory mechanisms of NKT cells. Targeting invariant NKT cells with specific glycolipids that bind to CD1d might prove to be a powerful means of modulating autoimmunity.

UR - https://www.scopus.com/pages/publications/33748514564

UR - https://www.scopus.com/pages/publications/33748514564#tab=citedBy

U2 - 10.1016/j.ddmec.2006.05.002

DO - 10.1016/j.ddmec.2006.05.002

M3 - Review article

AN - SCOPUS:33748514564

SN - 1740-6765

VL - 3

SP - 193

EP - 198

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 2

ER -

Invariant NKT cell regulation of autoimmunity

Abstract

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this