Invadopodia and podosomes in tumor invasion

Hideki Yamaguchi, Fiona Pixley, John Condeelis

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


Cell migration through the extracellular matrix (ECM) is necessary for cancer cells to invade adjacent tissues and metastasize to an organ distant from primary tumors. Highly invasive carcinoma cells form ECM-degrading membrane protrusions called invadopodia. Tumor-associated macrophages have been shown to promote the migratory phenotypes of carcinoma cells, and macrophages are known to form podosomes, similar structures to invadopodia. However, the role of invadopodia and podosomes in vivo remains to be determined. In this paper, we propose a model for possible functions and interactions of invadopodia and podosomes in tumor invasion, based on observations that macrophage podosomes degrade ECM and that podosome formation is regulated by colony-stimulating factor-1 signaling.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalEuropean Journal of Cell Biology
Issue number3-4
StatePublished - Apr 7 2006


  • CSF-1
  • Carcinoma
  • EGF
  • Invadopodia
  • Invasion
  • Macrophage
  • Metastasis
  • N-WASP
  • Podosomes
  • WASP

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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