Intraperitoneal administration of recombinant human erythropoietin in uremic animals

J. M. Bargman; A. Breborowicz; H. Rodela; K. Sombolos; D. G. Oreopoulos

doi:10.1177/089686088800800404

Intraperitoneal administration of recombinant human erythropoietin in uremic animals

J. M. Bargman, A. Breborowicz, H. Rodela, K. Sombolos, D. G. Oreopoulos

Obstetrics & Gynecology and Women's Health

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Previous protocols of administration of recombinant human erythropoietin to patients with end-stage renal disease have been by the i.v. route. Because this method would be impractical for the continuous ambulatory peritoneal dialysis patient, we designed an i.p. dosing protocol in uremic rabbits to examine whether significant amounts of this hormone could be absorbed from the peritoneal cavity. Our results demonstrate that almost all of the erythropoietin is absorbed (or absorbed) during a prolonged dwell when administered undiluted by dialysate.

Original language	English (US)
Pages (from-to)	249-252
Number of pages	4
Journal	Peritoneal Dialysis International
Volume	8
Issue number	4
DOIs	https://doi.org/10.1177/089686088800800404
State	Published - Jan 1 1988

ASJC Scopus subject areas

Nephrology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/089686088800800404

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AU - Oreopoulos, D. G.

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AB - Previous protocols of administration of recombinant human erythropoietin to patients with end-stage renal disease have been by the i.v. route. Because this method would be impractical for the continuous ambulatory peritoneal dialysis patient, we designed an i.p. dosing protocol in uremic rabbits to examine whether significant amounts of this hormone could be absorbed from the peritoneal cavity. Our results demonstrate that almost all of the erythropoietin is absorbed (or absorbed) during a prolonged dwell when administered undiluted by dialysate.

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Intraperitoneal administration of recombinant human erythropoietin in uremic animals

Abstract

ASJC Scopus subject areas

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