Intestinal and multivisceral transplantation

Tomoaki Kato; Phillip Ruiz; John F. Thompson; Lon B. Eskind; Deborah Weppler; Farrukh A. Khan; Antonio D. Pinna; Jose R. Nery; Andreas G. Tzakis

doi:10.1007/s00268-001-0210-5

Intestinal and multivisceral transplantation

Tomoaki Kato, Phillip Ruiz, John F. Thompson, Lon B. Eskind, Deborah Weppler, Farrukh A. Khan, Antonio D. Pinna, Jose R. Nery, Andreas G. Tzakis

Research output: Contribution to journal › Review article › peer-review

119 Scopus citations

Abstract

Intestinal transplantation has been gradually instituted in the management of intestinal failure. More than 200 cases including isolated intestinal transplant, liver/intestinal transplant, and multivisceral transplant have been performed worldwide, with 1-year graft and patient survival rates of 66% and 54%, respectively. Indications for the procedure include short bowel syndrome and functional abnormalities secondary to a variety of diseases or conditions. Tacrolimus-based immunosuppression regimens have been used universally with improved outcomes. The major contributors to the morbidity and mortality include rejection, infection, and technical complications. Of those, control of rejection remains the most difficult dilemma and it will be the key to improved patient and graft survival.

Original language	English (US)
Pages (from-to)	226-237
Number of pages	12
Journal	World Journal of Surgery
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/s00268-001-0210-5
State	Published - Feb 2002
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1007/s00268-001-0210-5

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title = "Intestinal and multivisceral transplantation",

abstract = "Intestinal transplantation has been gradually instituted in the management of intestinal failure. More than 200 cases including isolated intestinal transplant, liver/intestinal transplant, and multivisceral transplant have been performed worldwide, with 1-year graft and patient survival rates of 66% and 54%, respectively. Indications for the procedure include short bowel syndrome and functional abnormalities secondary to a variety of diseases or conditions. Tacrolimus-based immunosuppression regimens have been used universally with improved outcomes. The major contributors to the morbidity and mortality include rejection, infection, and technical complications. Of those, control of rejection remains the most difficult dilemma and it will be the key to improved patient and graft survival.",

author = "Tomoaki Kato and Phillip Ruiz and Thompson, {John F.} and Eskind, {Lon B.} and Deborah Weppler and Khan, {Farrukh A.} and Pinna, {Antonio D.} and Nery, {Jose R.} and Tzakis, {Andreas G.}",

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T1 - Intestinal and multivisceral transplantation

AU - Kato, Tomoaki

AU - Ruiz, Phillip

AU - Thompson, John F.

AU - Eskind, Lon B.

AU - Weppler, Deborah

AU - Khan, Farrukh A.

AU - Pinna, Antonio D.

AU - Nery, Jose R.

AU - Tzakis, Andreas G.

PY - 2002/2

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N2 - Intestinal transplantation has been gradually instituted in the management of intestinal failure. More than 200 cases including isolated intestinal transplant, liver/intestinal transplant, and multivisceral transplant have been performed worldwide, with 1-year graft and patient survival rates of 66% and 54%, respectively. Indications for the procedure include short bowel syndrome and functional abnormalities secondary to a variety of diseases or conditions. Tacrolimus-based immunosuppression regimens have been used universally with improved outcomes. The major contributors to the morbidity and mortality include rejection, infection, and technical complications. Of those, control of rejection remains the most difficult dilemma and it will be the key to improved patient and graft survival.

AB - Intestinal transplantation has been gradually instituted in the management of intestinal failure. More than 200 cases including isolated intestinal transplant, liver/intestinal transplant, and multivisceral transplant have been performed worldwide, with 1-year graft and patient survival rates of 66% and 54%, respectively. Indications for the procedure include short bowel syndrome and functional abnormalities secondary to a variety of diseases or conditions. Tacrolimus-based immunosuppression regimens have been used universally with improved outcomes. The major contributors to the morbidity and mortality include rejection, infection, and technical complications. Of those, control of rejection remains the most difficult dilemma and it will be the key to improved patient and graft survival.

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Intestinal and multivisceral transplantation

Abstract

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