Integrin signalling during tumour progression

Wenjun Guo, Filippo G. Giancotti

Research output: Contribution to journalReview articlepeer-review

1232 Scopus citations


During progression from tumour growth to metastasis, specific integrin signals enable cancer cells to detach from neighbouring cells, re-orientate their polarity during migration, and survive and proliferate in foreign microenvironments. There is increasing evidence that certain integrins associate with receptor tyrosine kinases (RTKs) to activate signalling pathways that are necessary for tumour invasion and metastasis. The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs.

Original languageEnglish (US)
Pages (from-to)816-826
Number of pages11
JournalNature Reviews Molecular Cell Biology
Issue number10
StatePublished - Oct 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Integrin signalling during tumour progression'. Together they form a unique fingerprint.

Cite this