TY - JOUR
T1 - Integrin signalling during tumour progression
AU - Guo, Wenjun
AU - Giancotti, Filippo G.
N1 - Funding Information:
Research in the authors' laboratory is supported by grants from the National Institutes of Health.
PY - 2004/10
Y1 - 2004/10
N2 - During progression from tumour growth to metastasis, specific integrin signals enable cancer cells to detach from neighbouring cells, re-orientate their polarity during migration, and survive and proliferate in foreign microenvironments. There is increasing evidence that certain integrins associate with receptor tyrosine kinases (RTKs) to activate signalling pathways that are necessary for tumour invasion and metastasis. The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs.
AB - During progression from tumour growth to metastasis, specific integrin signals enable cancer cells to detach from neighbouring cells, re-orientate their polarity during migration, and survive and proliferate in foreign microenvironments. There is increasing evidence that certain integrins associate with receptor tyrosine kinases (RTKs) to activate signalling pathways that are necessary for tumour invasion and metastasis. The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs.
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U2 - 10.1038/nrm1490
DO - 10.1038/nrm1490
M3 - Review article
C2 - 15459662
AN - SCOPUS:5044238876
SN - 1471-0072
VL - 5
SP - 816
EP - 826
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 10
ER -
