Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression

Nina Linde, Maria Soledad Sosa, Julio A. Aguirre-Ghiso

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Genetic alterations can drive oncogenic events and cancer development. However, this is only half of the story. It is now evident that tumor progression only occurs if powerful stress signaling pathways and microenvironmental signals are overcome. Two recent Nature Cell Biology papers study how niche signals of primary and target organ barriers have to be overridden for oncogenes to allow for colorectal cancer (CRC) initiation and metastasis (Urosevic et al,; Whissell et al,). Two recent papers in NCB elucidate stromal signals and intrinsic cellular stress pathways as critical barriers for tumor progression and metastasis, respectively.

Original languageEnglish (US)
Pages (from-to)1737-1739
Number of pages3
JournalEMBO Journal
Issue number16
StatePublished - Aug 18 2014
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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