Integration of cancer genomics with treatment selection: From the genome to predictive biomarkers

Thomas J. Ow; Vlad C. Sandulache; Heath D. Skinner; Jeffrey N. Myers

doi:10.1002/cncr.28304

Integration of cancer genomics with treatment selection: From the genome to predictive biomarkers

Thomas J. Ow, Vlad C. Sandulache, Heath D. Skinner, Jeffrey N. Myers

Otorhinolaryngology - Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

The field of cancer genomics is rapidly advancing as new technology provides detailed genetic and epigenetic profiling of human cancers. The amount of new data available describing the genetic make-up of tumors is paralleled by rapid advances in drug discovery and molecular therapy currently under investigation to treat these diseases. This review summarizes the challenges and approaches associated with the integration of genomic data into the development of new biomarkers in the management of cancer.

Original language	English (US)
Pages (from-to)	3914-3928
Number of pages	15
Journal	Cancer
Volume	119
Issue number	22
DOIs	https://doi.org/10.1002/cncr.28304
State	Published - Nov 15 2013

Keywords

biologic markers
clinical trials as topic
computational biology
genomics
molecular targeted therapy
neoplasms
systems biology
therapeutics

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cncr.28304

Cite this

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title = "Integration of cancer genomics with treatment selection: From the genome to predictive biomarkers",

abstract = "The field of cancer genomics is rapidly advancing as new technology provides detailed genetic and epigenetic profiling of human cancers. The amount of new data available describing the genetic make-up of tumors is paralleled by rapid advances in drug discovery and molecular therapy currently under investigation to treat these diseases. This review summarizes the challenges and approaches associated with the integration of genomic data into the development of new biomarkers in the management of cancer.",

keywords = "biologic markers, clinical trials as topic, computational biology, genomics, molecular targeted therapy, neoplasms, systems biology, therapeutics",

author = "Ow, {Thomas J.} and Sandulache, {Vlad C.} and Skinner, {Heath D.} and Myers, {Jeffrey N.}",

year = "2013",

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language = "English (US)",

volume = "119",

pages = "3914--3928",

journal = "Cancer",

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T1 - Integration of cancer genomics with treatment selection

T2 - From the genome to predictive biomarkers

AU - Ow, Thomas J.

AU - Sandulache, Vlad C.

AU - Skinner, Heath D.

AU - Myers, Jeffrey N.

PY - 2013/11/15

Y1 - 2013/11/15

N2 - The field of cancer genomics is rapidly advancing as new technology provides detailed genetic and epigenetic profiling of human cancers. The amount of new data available describing the genetic make-up of tumors is paralleled by rapid advances in drug discovery and molecular therapy currently under investigation to treat these diseases. This review summarizes the challenges and approaches associated with the integration of genomic data into the development of new biomarkers in the management of cancer.

AB - The field of cancer genomics is rapidly advancing as new technology provides detailed genetic and epigenetic profiling of human cancers. The amount of new data available describing the genetic make-up of tumors is paralleled by rapid advances in drug discovery and molecular therapy currently under investigation to treat these diseases. This review summarizes the challenges and approaches associated with the integration of genomic data into the development of new biomarkers in the management of cancer.

KW - biologic markers

KW - clinical trials as topic

KW - computational biology

KW - genomics

KW - molecular targeted therapy

KW - neoplasms

KW - systems biology

KW - therapeutics

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UR - http://www.scopus.com/inward/citedby.url?scp=84887079931&partnerID=8YFLogxK

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DO - 10.1002/cncr.28304

M3 - Review article

C2 - 24037788

AN - SCOPUS:84887079931

SN - 0008-543X

VL - 119

SP - 3914

EP - 3928

JO - Cancer

JF - Cancer

IS - 22

ER -

Integration of cancer genomics with treatment selection: From the genome to predictive biomarkers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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