Intakes of vitamins A, C, and e and use of multiple vitamin supplements and risk of colon cancer: A pooled analysis of prospective cohort studies

Yikyung Park; Donna Spiegelman; David J. Hunter; Demetrius Albanes; Leif Bergkvist; Julie E. Buring; Jo L. Freudenheim; Edward Giovannucci; R. Alexandra Goldbohm; Lisa Harnack; Ikuko Kato; Vittorio Krogh; Michael F. Leitzmann; Paul J. Limburg; James R. Marshall; Marjorie L. McCullough; Anthony B. Miller; Thomas E. Rohan; Arthur Schatzkin; Roy Shore; Sabina Sieri; Meir J. Stampfer; Jarmo Virtamo; Matty Weijenberg; Walter C. Willett; Alicja Wolk; Shumin M. Zhang; Stephanie A. Smith-Warner

doi:10.1007/s10552-010-9549-y

Intakes of vitamins A, C, and e and use of multiple vitamin supplements and risk of colon cancer: A pooled analysis of prospective cohort studies

Yikyung Park, Donna Spiegelman, David J. Hunter, Demetrius Albanes, Leif Bergkvist, Julie E. Buring, Jo L. Freudenheim, Edward Giovannucci, R. Alexandra Goldbohm, Lisa Harnack, Ikuko Kato, Vittorio Krogh, Michael F. Leitzmann, Paul J. Limburg, James R. Marshall, Marjorie L. McCullough, Anthony B. Miller, Thomas E. Rohan, Arthur Schatzkin, Roy ShoreSabina Sieri, Meir J. Stampfer, Jarmo Virtamo, Matty Weijenberg, Walter C. Willett, Alicja Wolk, Shumin M. Zhang, Stephanie A. Smith-Warner

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Objective: To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Methods: Using the primary data from 13 cohort studies, we estimated study-and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Results: Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, >4,000 vs. ≤1,000 μg/day) for vitamin A, 0.81 (0.71-0.92, >600 vs. ≤100 mg/day) for vitamin C, and 0.78 (0.66-0.92, >200 vs. ≤6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96). Conclusions: Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.

Original language	English (US)
Pages (from-to)	1745-1757
Number of pages	13
Journal	Cancer Causes and Control
Volume	21
Issue number	11
DOIs	https://doi.org/10.1007/s10552-010-9549-y
State	Published - Nov 2010

Keywords

Cohort study
Colon cancer
Multivitamin
Pooled analysis
Vitamin A
Vitamin C
Vitamin E

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10552-010-9549-y

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Park, Y., Spiegelman, D., Hunter, D. J., Albanes, D., Bergkvist, L., Buring, J. E., Freudenheim, J. L., Giovannucci, E., Goldbohm, R. A., Harnack, L., Kato, I., Krogh, V., Leitzmann, M. F., Limburg, P. J., Marshall, J. R., McCullough, M. L., Miller, A. B., Rohan, T. E., Schatzkin, A., ... Smith-Warner, S. A. (2010). Intakes of vitamins A, C, and e and use of multiple vitamin supplements and risk of colon cancer: A pooled analysis of prospective cohort studies. Cancer Causes and Control, 21(11), 1745-1757. https://doi.org/10.1007/s10552-010-9549-y

Park, Y, Spiegelman, D, Hunter, DJ, Albanes, D, Bergkvist, L, Buring, JE, Freudenheim, JL, Giovannucci, E, Goldbohm, RA, Harnack, L, Kato, I, Krogh, V, Leitzmann, MF, Limburg, PJ, Marshall, JR, McCullough, ML, Miller, AB, Rohan, TE, Schatzkin, A, Shore, R, Sieri, S, Stampfer, MJ, Virtamo, J, Weijenberg, M, Willett, WC, Wolk, A, Zhang, SM & Smith-Warner, SA 2010, 'Intakes of vitamins A, C, and e and use of multiple vitamin supplements and risk of colon cancer: A pooled analysis of prospective cohort studies', Cancer Causes and Control, vol. 21, no. 11, pp. 1745-1757. https://doi.org/10.1007/s10552-010-9549-y

@article{132c00e44129485190b80a8855a3c531,

title = "Intakes of vitamins A, C, and e and use of multiple vitamin supplements and risk of colon cancer: A pooled analysis of prospective cohort studies",

abstract = "Objective: To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Methods: Using the primary data from 13 cohort studies, we estimated study-and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Results: Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, >4,000 vs. ≤1,000 μg/day) for vitamin A, 0.81 (0.71-0.92, >600 vs. ≤100 mg/day) for vitamin C, and 0.78 (0.66-0.92, >200 vs. ≤6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96). Conclusions: Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.",

keywords = "Cohort study, Colon cancer, Multivitamin, Pooled analysis, Vitamin A, Vitamin C, Vitamin E",

author = "Yikyung Park and Donna Spiegelman and Hunter, {David J.} and Demetrius Albanes and Leif Bergkvist and Buring, {Julie E.} and Freudenheim, {Jo L.} and Edward Giovannucci and Goldbohm, {R. Alexandra} and Lisa Harnack and Ikuko Kato and Vittorio Krogh and Leitzmann, {Michael F.} and Limburg, {Paul J.} and Marshall, {James R.} and McCullough, {Marjorie L.} and Miller, {Anthony B.} and Rohan, {Thomas E.} and Arthur Schatzkin and Roy Shore and Sabina Sieri and Stampfer, {Meir J.} and Jarmo Virtamo and Matty Weijenberg and Willett, {Walter C.} and Alicja Wolk and Zhang, {Shumin M.} and Smith-Warner, {Stephanie A.}",

note = "Funding Information: Financial support The study was funded by research grants CA55075 from the National Institutes of Health and the National Colorectal Cancer Research Alliance of the Entertainment Industry Foundation.",

year = "2010",

month = nov,

doi = "10.1007/s10552-010-9549-y",

language = "English (US)",

volume = "21",

pages = "1745--1757",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Netherlands",

number = "11",

}

TY - JOUR

T1 - Intakes of vitamins A, C, and e and use of multiple vitamin supplements and risk of colon cancer

T2 - A pooled analysis of prospective cohort studies

AU - Park, Yikyung

AU - Spiegelman, Donna

AU - Hunter, David J.

AU - Albanes, Demetrius

AU - Bergkvist, Leif

AU - Buring, Julie E.

AU - Freudenheim, Jo L.

AU - Giovannucci, Edward

AU - Goldbohm, R. Alexandra

AU - Harnack, Lisa

AU - Kato, Ikuko

AU - Krogh, Vittorio

AU - Leitzmann, Michael F.

AU - Limburg, Paul J.

AU - Marshall, James R.

AU - McCullough, Marjorie L.

AU - Miller, Anthony B.

AU - Rohan, Thomas E.

AU - Schatzkin, Arthur

AU - Shore, Roy

AU - Sieri, Sabina

AU - Stampfer, Meir J.

AU - Virtamo, Jarmo

AU - Weijenberg, Matty

AU - Willett, Walter C.

AU - Wolk, Alicja

AU - Zhang, Shumin M.

AU - Smith-Warner, Stephanie A.

N1 - Funding Information: Financial support The study was funded by research grants CA55075 from the National Institutes of Health and the National Colorectal Cancer Research Alliance of the Entertainment Industry Foundation.

PY - 2010/11

Y1 - 2010/11

N2 - Objective: To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Methods: Using the primary data from 13 cohort studies, we estimated study-and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Results: Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, >4,000 vs. ≤1,000 μg/day) for vitamin A, 0.81 (0.71-0.92, >600 vs. ≤100 mg/day) for vitamin C, and 0.78 (0.66-0.92, >200 vs. ≤6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96). Conclusions: Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.

AB - Objective: To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Methods: Using the primary data from 13 cohort studies, we estimated study-and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Results: Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, >4,000 vs. ≤1,000 μg/day) for vitamin A, 0.81 (0.71-0.92, >600 vs. ≤100 mg/day) for vitamin C, and 0.78 (0.66-0.92, >200 vs. ≤6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96). Conclusions: Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.

KW - Cohort study

KW - Colon cancer

KW - Multivitamin

KW - Pooled analysis

KW - Vitamin A

KW - Vitamin C

KW - Vitamin E

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DO - 10.1007/s10552-010-9549-y

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AN - SCOPUS:78449307671

SN - 0957-5243

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JO - Cancer Causes and Control

JF - Cancer Causes and Control

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ER -

Intakes of vitamins A, C, and e and use of multiple vitamin supplements and risk of colon cancer: A pooled analysis of prospective cohort studies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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