Insulin-like growth factor axis and oncogenic human papillomavirus natural history

Tiffany G. Harris, Robert D. Burk, Herbert Yu, Howard Minkoff, L. Stewart Massad, D. Heather Watts, Ye Zhong, Stephen Gange, Robert C. Kaplan, Kathryn Anastos, Alexandra M. Levine, Michael Moxley, Xiaonan Xue, Melissa Fazzari, Joel M. Palefsky, Howard D. Strickler

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


High serum levels of insulin-like growth factor-I (IGF-I) are reported to be a risk factor for several common cancers, and recent cross-sectional data suggest a possible additional association of IGF-I with cervical neoplasia. To prospectively assess whether circulating IGF-I levels influence the natural history of oncogenic human papillomavirus (HPV), the viral cause of cervical cancer, we conducted a pilot investigation of 137 women who underwent semiannual type specific HPV DNA PCR testing and cervical cytology. Total IGF-I and IGF binding protein-3 (IGFBP-3), the most abundant IGFBP in circulation, were measured using baseline serum specimens. Having a high IGF-I/ IGFBP-3 ratio was associated with increased persistence of oncogenic HPV infection [that is, a lower rate of clearance; adjusted hazard ratio (AHR), 0.14; 95% confidence interval (95% CI), 0.04-0.57], whereas IGFBP-3 was inversely associated with both the incident detection of oncogenic HPV (AHR, 0.35; 95% CI, 0.13-0.93) and the incidence of oncogenic HPV-positive cervical neoplasia (that is, squamous intraepithelial lesions at risk of progression; AHR, 0.07; 95% CI, 0.01-0.66). These prospective data provide initial evidence that the IGF axis may influence the natural history of oncogenic HPV.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Issue number1
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


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