TY - JOUR
T1 - Inject and infect
T2 - How Mycobacterium tuberculosis exploits its major virulence-associated type VII secretion system, ESX-1
AU - Tiwari, Sangeeta
AU - Casey, Rosalyn
AU - Goulding, Celia W.
AU - Hingley-Wilson, Suzie
AU - Jacobs, William R.
N1 - Funding Information:
We thank Keely R. Redhage for her help with proofreading and useful comments. We thank Tsungda Hsu for useful discussions related to RD1. This work was supported by grant R01AI026170.
Publisher Copyright:
© 2019 American Society for Microbiology.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Mycobacterium tuberculosis is an ancient master of the art of causing human disease. One important weapon within its fully loaded arsenal is the type VII secretion system. M. tuberculosis has five of them: ESAT-6 secretion systems (ESX) 1 to 5. ESX-1 has long been recognized as a major cause of attenuation of the FDA-licensed vaccine Mycobacterium bovis BCG, but its importance in disease progression and transmission has recently been elucidated in more detail. This review summarizes the recent advances in (i) the understanding of the ESX-1 structure and components, (ii) our knowledge of ESX-1's role in hijacking macrophage function to set a path for infection and dissemination, and (iii) the development of interventions that utilize ESX-1 for diagnosis, drug interventions, host-directed therapies, and vaccines.
AB - Mycobacterium tuberculosis is an ancient master of the art of causing human disease. One important weapon within its fully loaded arsenal is the type VII secretion system. M. tuberculosis has five of them: ESAT-6 secretion systems (ESX) 1 to 5. ESX-1 has long been recognized as a major cause of attenuation of the FDA-licensed vaccine Mycobacterium bovis BCG, but its importance in disease progression and transmission has recently been elucidated in more detail. This review summarizes the recent advances in (i) the understanding of the ESX-1 structure and components, (ii) our knowledge of ESX-1's role in hijacking macrophage function to set a path for infection and dissemination, and (iii) the development of interventions that utilize ESX-1 for diagnosis, drug interventions, host-directed therapies, and vaccines.
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U2 - 10.1128/microbiolspec.BAI-0024-2019
DO - 10.1128/microbiolspec.BAI-0024-2019
M3 - Article
C2 - 31172908
AN - SCOPUS:85066986711
SN - 2165-0497
VL - 7
JO - Microbiology Spectrum
JF - Microbiology Spectrum
IS - 3
M1 - BAI-0024-2019
ER -
