Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

Jianhua Ge; Yi Zhang; Zhirui Dong; Jianbo Jia; Jiannan Zhu; Xiaoyuan Miao; Bing Yan

doi:10.1021/acsami.7b05009

Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

Jianhua Ge
, Yi Zhang
, Zhirui Dong
, Jianbo Jia
, Jiannan Zhu
, Xiaoyuan Miao
, Bing Yan

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe₃O₄/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

Original language	English (US)
Pages (from-to)	20771-20778
Number of pages	8
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	24
DOIs	https://doi.org/10.1021/acsami.7b05009
State	Published - Jun 21 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

drug delivery
magnetic implant
nanocarrier
nanomedicine
targeting

ASJC Scopus subject areas

General Materials Science

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10.1021/acsami.7b05009

Cite this

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title = "Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant",

abstract = "Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.",

keywords = "drug delivery, magnetic implant, nanocarrier, nanomedicine, targeting",

author = "Jianhua Ge and Yi Zhang and Zhirui Dong and Jianbo Jia and Jiannan Zhu and Xiaoyuan Miao and Bing Yan",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

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doi = "10.1021/acsami.7b05009",

language = "English (US)",

volume = "9",

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journal = "ACS Applied Materials and Interfaces",

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T1 - Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

AU - Ge, Jianhua

AU - Zhang, Yi

AU - Dong, Zhirui

AU - Jia, Jianbo

AU - Zhu, Jiannan

AU - Miao, Xiaoyuan

AU - Yan, Bing

PY - 2017/6/21

Y1 - 2017/6/21

N2 - Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

AB - Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

KW - drug delivery

KW - magnetic implant

KW - nanocarrier

KW - nanomedicine

KW - targeting

UR - https://www.scopus.com/pages/publications/85021066407

UR - https://www.scopus.com/pages/publications/85021066407#tab=citedBy

U2 - 10.1021/acsami.7b05009

DO - 10.1021/acsami.7b05009

M3 - Article

C2 - 28557411

AN - SCOPUS:85021066407

SN - 1944-8244

VL - 9

SP - 20771

EP - 20778

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 24

ER -

Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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